Chronic Sensing of Subthalamic Local Field Potentials: Comparison of First and Second Generation Implantable Bidirectional Systems Within a Single Subject.
Chronic Sensing of Subthalamic Local Field Potentials: Comparison of First and Second Generation Implantable Bidirectional Systems Within a Single Subject.
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DOI：
10.3389/fnins.2021.725797
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发表时间：
2021
影响因子：
4.3
通讯作者：
Starr PA
中科院分区：
文献类型：
--
作者：
Cummins DD;Kochanski RB;Gilron R;Swann NC;Little S;Hammer LH;Starr PA
许多适应性脑深部刺激（DBS）模式依赖于感知特定临床体征或症状的神经特征的能力，以调节治疗性刺激。在第一代双向神经刺激器中，在主动刺激过程中感知神经信号的能力经常受到伪影的限制。最近已经开发出具有改进的传感设计规格的新设备，并且现已临床可用。比较第一代美敦力PC + S和第二代perceptpc神经刺激器在单个患者中的传感能力。一名患有帕金森病的42岁男子最初植入了左STN DBS导线，连接到PC + S植入式脉冲发生器。四年后，PC + S被Percept PC所取代。在每个设备的多个时间点记录局部场电位（LFP）信号，包括刺激关闭和打开，并进行比较。时间序列数据的离线处理包括使用数字滤波和模板减法去除伪影，然后进行后续的频谱分析。在perceptpc中，还采用了窄频带内频谱功率的嵌入式处理。在没有刺激的情况下，两个装置都在β范围内显示出峰值（约20 Hz），在整个4年期间保持稳定。与之前的报道类似，在主动增产期间，PC + S的记录显示了明显的刺激伪影，限制了恢复有意义的LFP信号的能力。相比之下，Percept PC使用相同的电极和刺激设置，在刺激过程中产生时间序列数据，光谱分析显示β波段有一个峰值。percepept的在线分析表明，随着刺激幅度的增加，β -波段活性降低。本报告重点介绍了用于DBS的植入式神经刺激器技术的最新进展，展示了第一代和第二代设备在主动刺激期间感知能力的改进。在刺激过程中可靠感知的能力是自适应算法临床应用和进一步研究运动障碍的神经生理学基础的重要一步。
Many adaptative deep brain stimulation (DBS) paradigms rely upon the ability to sense neural signatures of specific clinical signs or symptoms in order to modulate therapeutic stimulation. In first-generation bidirectional neurostimulators, the ability to sense neural signals during active stimulation was often limited by artifact. Newer devices, with improved design specifications for sensing, have recently been developed and are now clinically available. To compare the sensing capabilities of the first-generation Medtronic PC + S and second-generation Percept PC neurostimulators within a single patient. A 42-year-old man with Parkinson’s disease was initially implanted with left STN DBS leads connected to a PC + S implantable pulse generator. Four years later, the PC + S was replaced with the Percept PC. Local field potential (LFP) signals were recorded, both with stimulation OFF and ON, at multiple timepoints with each device and compared. Offline processing of time series data included artifact removal using digital filtering and template subtraction, before subsequent spectral analysis. With Percept PC, embedded processing of spectral power within a narrow frequency band was also utilized. In the absence of stimulation, both devices demonstrated a peak in the beta range (approximately 20 Hz), which was stable throughout the 4-year period. Similar to previous reports, recordings with the PC + S during active stimulation demonstrated significant stimulation artifact, limiting the ability to recover meaningful LFP signal. In contrast, the Percept PC, using the same electrodes and stimulation settings, produced time series data during stimulation with spectral analysis revealing a peak in the beta-band. Online analysis by the Percept demonstrated a reduction in beta-band activity with increasing stimulation amplitude. This report highlights recent advances in implantable neurostimulator technology for DBS, demonstrating improvements in sensing capabilities during active stimulation between first- and second-generation devices. The ability to reliably sense during stimulation is an important step toward both the clinical implementation of adaptive algorithms and the further investigation into the neurophysiology underlying movement disorders.
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影响因子：
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作者：
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影响因子：
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影响因子：
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作者：
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通讯作者：
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DOI：
10.1109/tbcas.2018.2880148
发表时间：
2018-12-01
影响因子：
5.1
作者：
Stanslaski, Scott;Herron, Jeffrey;Denison, Timothy
通讯作者：
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影响因子：
46.9
作者：
Gilron R;Little S;Perrone R;Wilt R;de Hemptinne C;Yaroshinsky MS;Racine CA;Wang SS;Ostrem JL;Larson PS;Wang DD;Galifianakis NB;Bledsoe IO;San Luciano M;Dawes HE;Worrell GA;Kremen V;Borton DA;Denison T;Starr PA
通讯作者：
Starr PA