Multifunctional imaging nanoprobes.
Multifunctional imaging nanoprobes.
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DOI：
10.1002/wnan.72
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发表时间：
2010-03
影响因子：
8.6
通讯作者：
Mulder, Willem J. M.
中科院分区：
文献类型：
--
作者：
Jarzyna, Peter A.;Gianella, Anita;Skajaa, Torjus;Knudsen, Gitte;Deddens, Lisette H.;Cormode, David P.;Fayad, Zahi A.;Mulder, Willem J. M.
多功能成像纳米探针已被证明在病理过程研究以及封装药物的递送、命运和治疗潜力的评估中具有巨大价值。此外，此类探针可能通过利用其自身的物理特性（例如通过热消融）来支持治疗方案。本综述将介绍该领域使用的四类纳米颗粒成像探针：多功能探针（1）可以使用至少三种不同且互补的成像技术进行追踪，（2）携带药物并具有双峰成像特性，（3）用于核酸输送和成像，以及（4）具有可用于热消融功能的成像探针。我们将重点介绍几个例子，其中可以定制不同（生物）材料（如聚合物、无机纳米晶体、荧光团、蛋白质/肽和脂质）的适当组合来制造多功能探针，以实现上述每一类纳米材料。此外，还将展示多模态成像方法如何提高我们对从亚细胞水平到全身不同水平的体内纳米颗粒行为和功效的理解。
Multifunctional imaging nanoprobes have proven to be of great value in the research of pathological processes, as well as the assessment of the delivery, fate, and therapeutic potential of encapsulated drugs. Moreover, such probes may potentially support therapy schemes by the exploitation of their own physical properties, e.g., through thermal ablation. This review will present four classes of nanoparticulate imaging probes used in this area: multifunctional probes (1) that can be tracked with at least three different and complementary imaging techniques, (2) that carry a drug and have bimodal imaging properties, (3) that are employed for nucleic acid delivery and imaging, and (4) imaging probes with capabilities that can be used for thermal ablation. We will highlight several examples where the suitable combination of different (bio)materials like polymers, inorganic nanocrystals, fluorophores, proteins/peptides, and lipids can be tailored to manufacture multifunctional probes to accomplish nanomaterials of each of the aforementioned classes. Moreover, it will be demonstrated how multimodality imaging approaches improve our understanding of in vivo nanoparticle behavior and efficacy at different levels, ranging from the subcellular level to the whole body.
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