Increasing levels of Parasutterella in the gut microbiome correlate with improving low-density lipoprotein levels in healthy adults consuming resistant potato starch during a randomised trial.
Increasing levels of Parasutterella in the gut microbiome correlate with improving low-density lipoprotein levels in healthy adults consuming resistant potato starch during a randomised trial.
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DOI：
10.1186/s40795-020-00398-9
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发表时间：
2020-12-11
期刊：
影响因子：
2
通讯作者：
Alfa MJ
中科院分区：
文献类型：
--
作者：
Bush JR;Alfa MJ
益生元被定义为宿主微生物选择性利用的底物，赋予健康益处，是优化肠道微生物组健康的潜在选择。阐明特定肠道细菌，益生元摄入量和宿主健康之间的关系仍然是微生物组研究的主要目标。评估健康成年人肠道微生物群、血清健康参数和益生元摄入量之间的相关性。我们对来自随机安慰剂对照临床试验的75名参与者的肠道微生物组中属的丰度变化进行了专门的探索性分析，该临床试验评估了抗性马铃薯淀粉（RPS; MSPrebiotic®，N = 38）干预与完全可消化的安慰剂（N = 37）的影响，其主要和次要结果先前已发表。Pearson相关分析用于确定健康参数（即，血糖和脂质）和肠道细菌群。Parasutterella（变形菌门）的减少倾向于增加消耗RPS的个体的肠道微生物组，并且Parasutterella的增加与消耗RPS而不是安慰剂的参与者的低密度脂蛋白（LDL）水平的降低相关。将低密度脂蛋白水平降低的消耗RPS的个体（即“应答者”）与那些没有降低的个体（即“应答者”）分开。“无应答者”）显示，LDL应答者在基线和食用RPS 12周后均具有显著更高水平的副小蠹。我们的分析表明，RPS可能有助于改善LDL水平，这取决于个体肠道微生物组中的副苏氏菌水平。本研究方案由加拿大卫生部审查并批准（提交编号188517;“授权通知”，日期2013年6月5日），并在NIH网站ClinicalTrials. gov上注册为NCT 01977183（2013年10月11日）。本研究生成的数据已提交至NCBI（http：//www.ncbi.nlm.nih.gov/bioproject/381931）。MSP淀粉产品公司
Prebiotics, defined as a substrate that is selectively utilized by host microorganisms conferring a health benefit, present a potential option to optimize gut microbiome health. Elucidating the relationship between specific intestinal bacteria, prebiotic intake, and the health of the host remains a primary microbiome research goal. To assess the correlations between gut microbiota, serum health parameters, and prebiotic consumption in healthy adults. We performed ad hoc exploratory analysis of changes in abundance of genera in the gut microbiome of 75 participants from a randomized, placebo-controlled clinical trial that evaluated the effects of resistant potato starch (RPS; MSPrebiotic®, N = 38) intervention versus a fully digestible placebo (N = 37) for which primary and secondary outcomes have previously been published. Pearson correlation analysis was used to identify relationships between health parameters (ie. blood glucose and lipids) and populations of gut bacteria. Abundance of Parasutterella (phylum Proteobacteria) tended to increase in the gut microbiome of individuals consuming RPS and those increases in Parasutterella were correlated with reductions in low-density lipoprotein (LDL) levels in participants consuming RPS but not placebo. Segregating RPS-consuming individuals whose LDL levels decreased (ie “Responders”) from those who did not (ie. “Non-Responders”) revealed that LDL Responders had significantly higher levels of Parasutterella both at baseline and after 12 weeks of consuming RPS. Our analyses suggest that RPS may help improve LDL levels depending upon the levels of Parasutterella in an individual’s gut microbiome. This study protocol was reviewed and approved by Health Canada (Submission #188517; “Notice of Authorization” dated 06/05/13) and registered as NCT01977183 (10/11/13) listed on NIH website: ClinicalTrials.gov. Data generated in this study have been submitted to NCBI (http://www.ncbi.nlm.nih.gov/bioproject/381931). MSP Starch Products Inc.
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影响因子：
24.5
作者：
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通讯作者：
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5.2
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影响因子：
3.9
作者：
Alfa MJ;Strang D;Tappia PS;Olson N;DeGagne P;Bray D;Murray BL;Hiebert B
通讯作者：
Hiebert B
影响因子：
4.4
作者：
Schloss, Patrick D.;Westcott, Sarah L.;Weber, Carolyn F.
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DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y