Learning enhances encoding of time and temporal surprise in mouse primary sensory cortex.
Learning enhances encoding of time and temporal surprise in mouse primary sensory cortex.
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DOI：
10.1038/s41467-022-33141-y
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发表时间：
2022-09-20
影响因子：
16.6
通讯作者：
中科院分区：
文献类型：
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作者：
长期以来，初级感觉皮层被认为在感觉信息的初始处理中起着直接的作用。然而，即使在感觉刺激期间，皮层的表层总体上也是稀疏活跃的;此外，皮层活动受到其他形式，任务背景，奖励和行为状态的影响。我们的研究表明，强化学习显着改变纵向成像的神经元在小鼠初级躯体感觉皮层的浅层的代表。学习物体检测任务招募了以前没有反应的神经元，扩大了对触摸和行为选择敏感的神经元群体。在行为任务之外的重复刺激呈现时，皮层反应降低。此外，训练提高了群体对时间流逝的编码，并且试验时间的意外偏差引起比触摸更强烈的反应。总之，感觉皮层的表层表现出高度的学习依赖性可塑性，并受到非感觉但与行为相关的特征（如时机和惊喜）的强烈调制。感觉皮层表层的活动被认为主要是由传入的感觉刺激驱动的。在这里，作者展示了学习如何根据行为相关性和时间来改变神经对感觉的反应，这表明了高度的非感觉调节。
Primary sensory cortex has long been believed to play a straightforward role in the initial processing of sensory information. Yet, the superficial layers of cortex overall are sparsely active, even during sensory stimulation; additionally, cortical activity is influenced by other modalities, task context, reward, and behavioral state. Our study demonstrates that reinforcement learning dramatically alters representations among longitudinally imaged neurons in superficial layers of mouse primary somatosensory cortex. Learning an object detection task recruits previously unresponsive neurons, enlarging the neuronal population sensitive to touch and behavioral choice. Cortical responses decrease upon repeated stimulus presentation outside of the behavioral task. Moreover, training improves population encoding of the passage of time, and unexpected deviations in trial timing elicit even stronger responses than touches do. In conclusion, the superficial layers of sensory cortex exhibit a high degree of learning-dependent plasticity and are strongly modulated by non-sensory but behaviorally-relevant features, such as timing and surprise. Activity in the superficial layers of the sensory cortex is believed to be largely driven by incoming sensory stimuli. Here the authors demonstrate how learning changes neural responses to sensations according to both behavioral relevance and timing, suggesting a high degree of non-sensory modulation.
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DOI：
10.1093/cercor/bhn161
发表时间：
2009-05
期刊：
Cerebral cortex (New York, N.Y. : 1991)
影响因子：
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作者：
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发表时间：
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影响因子：
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影响因子：
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影响因子：
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