Tight junctions in Schwann cells of peripheral myelinated axons: a lesson from claudin-19-deficient mice.
Tight junctions in Schwann cells of peripheral myelinated axons: a lesson from claudin-19-deficient mice.
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DOI：
10.1083/jcb.200501154
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发表时间：
2005-05-09
期刊：
影响因子：
--
通讯作者：
Tsukita S
中科院分区：
文献类型：
--
作者：
Miyamoto T;Morita K;Takemoto D;Takeuchi K;Kitano Y;Miyakawa T;Nakayama K;Okamura Y;Sasaki H;Miyachi Y;Furuse M;Tsukita S
紧连接(TJ)样结构在雪旺细胞中已有报道，但其分子组成和生理功能仍不清楚。我们发现Claudin-19是Claudin家族的一个新成员(上皮细胞中的TJ黏附分子)，构成了这些结构。产生了Claudin-19缺陷的小鼠，它们表现出行为异常，这些异常可以归因于周围神经系统的缺陷。电生理分析显示，Claudin-19缺陷影响了外周有髓纤维的神经传导。有趣的是，缺乏claudin-19表达的雪旺细胞的整体形态似乎是正常的，不仅在结间区，在Ranvier结节，除了TJ完全消失，至少从外/内中轴突。这些发现表明，与上皮细胞类似，雪旺细胞也具有基于Claudin的TJ，并提示这些TJ不参与极化的形态发生，而参与雪旺细胞的电生理“封闭”功能。
Tight junction (TJ)–like structures have been reported in Schwann cells, but their molecular composition and physiological function remain elusive. We found that claudin-19, a novel member of the claudin family (TJ adhesion molecules in epithelia), constituted these structures. Claudin-19–deficient mice were generated, and they exhibited behavioral abnormalities that could be attributed to peripheral nervous system deficits. Electrophysiological analyses showed that the claudin-19 deficiency affected the nerve conduction of peripheral myelinated fibers. Interestingly, the overall morphology of Schwann cells lacking claudin-19 expression appeared to be normal not only in the internodal region but also at the node of Ranvier, except that TJs completely disappeared, at least from the outer/inner mesaxons. These findings have indicated that, similar to epithelial cells, Schwann cells also bear claudin-based TJs, and they have also suggested that these TJs are not involved in the polarized morphogenesis but are involved in the electrophysiological “sealing” function of Schwann cells.
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影响因子：
7.8
作者：
Einheber, S;Zanazzi, G;Ching, W;Scherer, S;Milner, TA;Peles, E;Salzer, JL
通讯作者：
Salzer, JL
影响因子：
11.8
作者：
Behr, M;Riedel, D;Schuh, R
通讯作者：
Schuh, R
DOI：
10.1083/jcb.147.1.185
发表时间：
1999-10-04
期刊：
The Journal of cell biology
影响因子：
--
作者：
Morita K;Sasaki H;Furuse M;Tsukita S
通讯作者：
Tsukita S
影响因子：
3.6
作者：
DERMIETZ.R
通讯作者：
DERMIETZ.R
新型的E-钙粘蛋白介导的外周神经：Schwann细胞结构的粘附稳定在自动型粘附连接处。
影响因子：
7.8
作者：
Fannon, A M;Sherman, D L;Ilyina-Gragerova, G;Brophy, P J;Friedrich, V L Jr;Colman, D R
通讯作者：
Colman, D R