Kv1.1 contributes to a rapid homeostatic plasticity of intrinsic excitability in CA1 pyramidal neurons in vivo
Kv1.1 contributes to a rapid homeostatic plasticity of intrinsic excitability in CA1 pyramidal neurons in vivo
复制标题
Kv1.1 有助于体内 CA1 锥体神经元内在兴奋性的快速稳态可塑性
作者：
P. Morgan;Romain Bourboulou;Caroline Filippi;Julie Koenig;J. Epsztein
在海马CA 1区，代表新环境的位置细胞的选择偏向于具有较高兴奋性的神经元。然而，不同的环境是由正交细胞系综，表明存在的监管机制。在体外观察到的内在兴奋性的活动依赖性可塑性是一个有吸引力的候选者。在这里，使用全细胞膜片钳记录麻醉大鼠的CA 1锥体神经元，我们研究了如何诱导θ-爆发的动作电位影响其内在的兴奋性随着时间的推移。我们观察到一个持久的，稳态抑郁症的内在兴奋性，在几分钟内开始，并在体外观察相反，不介导的树突状Ih。相反，它被衰减Kv1.1通道阻断剂树毒素K，这表明轴突起源。对在虚拟现实中导航的小鼠的位置细胞的场外放电的分析进一步揭示了与兴奋性降低一致的经验依赖性降低。我们建议，这种机制可以减少内存干扰。
In area CA1 of the hippocampus, the selection of place cells to represent a new environment is biased towards neurons with higher excitability. However, different environments are represented by orthogonal cell ensembles, suggesting that regulatory mechanisms exist. Activity-dependent plasticity of intrinsic excitability, as observed in vitro, is an attractive candidate. Here, using whole-cell patch-clamp recordings of CA1 pyramidal neurons in anesthetized rats, we have examined how inducing theta-bursts of action potentials affects their intrinsic excitability over time. We observed a long-lasting, homeostatic depression of intrinsic excitability which commenced within minutes, and, in contrast to in vitro observations, was not mediated by dendritic Ih. Instead, it was attenuated by the Kv1.1 channel blocker dendrotoxin K, suggesting an axonal origin. Analysis of place cells’ out-of-field firing in mice navigating in virtual reality further revealed an experience-dependent reduction consistent with decreased excitability. We propose that this mechanism could reduce memory interference.
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DOI：
10.1073/pnas.94.16.8918
发表时间：
1997-08-05
影响因子：
11.1
作者：
Mehta, MR;Barnes, CA;McNaughton, BL
通讯作者：
McNaughton, BL
影响因子：
56.9
作者：
TURRIGIANO, G;ABBOTT, LF;MARDER, E
通讯作者：
MARDER, E
DOI：
--
发表时间：
--
期刊：
--
影响因子：
--
作者：
A. Pearson;B. J. Johnson;C. Wilmot;D. Ohlendorf;Jin-Hee Han;S. Kushner;A. Yiu;C. J. Cole;Alcino J. Silva;S. Josselyn
通讯作者：
A. Pearson;B. J. Johnson;C. Wilmot;D. Ohlendorf;Jin-Hee Han;S. Kushner;A. Yiu;C. J. Cole;Alcino J. Silva;S. Josselyn
影响因子：
14.8
作者：
Lee, Albert K.;Epsztein, Jerome;Brecht, Michael
通讯作者：
Brecht, Michael
影响因子：
2.5
作者：
Oh, MM;Kuo, AG;Disterhoft, JF
通讯作者：
Disterhoft, JF