Both IgM and IgG anti-DNA antibodies are the products of clonally selective B cell stimulation in (NZB x NZW)F1 mice.
Both IgM and IgG anti-DNA antibodies are the products of clonally selective B cell stimulation in (NZB x NZW)F1 mice.
复制标题
IgM和IgG抗DNA抗体都是克隆选择性B细胞刺激的产物（NZB X NZW）小鼠。
DOI：
10.1084/jem.176.3.761
复制
发表时间：
1992-09-01
影响因子：
15.3
通讯作者：
MARION, TN
中科院分区：
文献类型：
--
作者：
TILLMAN, DM;JOU, NT;HILL, RJ;MARION, TN
Disease activity in systemic lupus erythematosus is closely associated with the appearance of immunoglobulin (Ig)G antibody to native DNA in both humans and mice. Like normal antibody responses, the anti-DNA autoantibody first appears as IgM and then switches to IgG. Structural studies of IgG anti-DNA suggest that these antibodies are the products of clonally selected, specifically stimulated B cells. The origins of the IgM anti-DNA have been less clear. To determine whether the earlier appearing IgM anti-DNA antibody in autoimmune mice also derives from clonally selected, specifically stimulated B cells or B cells activated by nonselective, polyclonal stimuli, we have analyzed the molecular and serological characteristics of a large number of monoclonal IgM anti- DNA antibodies from autoimmune (NZB x NZW)F1 mice. We have also analyzed IgM and IgG anti-DNA hybridomas obtained from the same individual mice to determine how the later-appearing IgG autoantibody may be related to the earlier-appearing IgM autoantibody within an individual mouse. The results demonstrate that: (a) IgM anti-DNA, like IgG, has the characteristics of a specifically stimulated antibody; (b) IgM and IgG anti-DNA antibodies have similar variable region structures and within individual mice may be produced by B cells derived from the same clonal precursors; (c) recurrent germline and somatically derived VH and VL structures may influence the specificity of anti-DNA monoclonal antibody for denatured vs. native DNA; and (d) the results provide a structural explanation for the selective development of IgG antibody to native DNA as autoimmunity to DNA progresses in (NZB x NZW)F1 mice.
登录
查看更多内容
DOI：
10.1073/pnas.79.10.3280
发表时间：
1982-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
CLARKE, SH;CLAFLIN, JL;RUDIKOFF, S
通讯作者：
RUDIKOFF, S
DOI：
10.1016/0090-1229(84)90061-8
发表时间：
1984-01-01
期刊：
CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY
影响因子：
--
作者：
DANG, H;HARBECK, RJ
通讯作者：
HARBECK, RJ
影响因子：
3.6
作者：
BRILES, DE;CARROLL, RJ
通讯作者：
CARROLL, RJ
影响因子：
3.1
作者：
CRAIN, MJ;WALTMAN, WD;BRILES, DE
通讯作者：
BRILES, DE
影响因子：
64.8
作者：
DESIDERIO, SV;YANCOPOULOS, GD;BALTIMORE, D
通讯作者：
BALTIMORE, D