Exercise training improves hemodynamic recovery to isometric exercise in obese men with type 2 diabetes but not in obese women.
Exercise training improves hemodynamic recovery to isometric exercise in obese men with type 2 diabetes but not in obese women.
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DOI：
10.1016/j.metabol.2012.07.014
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发表时间：
2012-12
影响因子：
9.8
通讯作者：
Fernhall, Bo
中科院分区：
文献类型：
--
作者：
Kanaley, Jill A.;Goulopoulou, Styliani;Franklin, Ruth;Baynard, Tracy;Carhart, Robert L., Jr.;Weinstock, Ruth S.;Fernhall, Bo
2型糖尿病（T2 D）女性患者因缺血性心脏病的死亡率高于男性患者。我们的目的是检查心血管和自主神经功能的反应，等距握（IHG）运动的男性和女性之间的T2 D，之前和之后的运动训练计划。在22名男性和女性T2 D患者中，在3分钟IHG试验期间和之后，以及16周有氧运动训练之前和之后，测量了血流动力学反应。在IHG恢复期间，女性的平均动脉压（MAP）和收缩压（BP）下降幅度（ΔMAPREC）均小于男性（P<0.05）。在从IHG恢复期间，男性的舒张压下降幅度更大（P<0.05），运动训练改善了男性的这一反应，但女性没有（男性，训练前：-13.9 ±1.8 mmHg，训练后：-20.5 ±5.3 mmHg vs.女性，训练前：-10.7 ±1.7 mmHg，训练后：-4.1 ±4.9 mmHg; P<0.05）。根据血压变异性估计，IHG后，男性交感神经对血管紧张度的调节作用降低更大（P<0.05）。这种反应在训练后加重，而这种训练效果在女性中未见。训练后ΔMAPREC与BP频谱低频成分恢复相关（ΔLFSBPrec，r=0.52，P<0.05）。IHG后即刻血压恢复的差异可能归因于心血管自主调节的性别差异。这些反应的改善发生在肥胖男性的有氧运动训练后，但在患有T2 D的肥胖女性中没有，这反映了对运动训练的更好的适应性自主反应。
Women with type 2 diabetes (T2D) show greater rates of mortality due to ischemic heart disease than men with T2D. We aimed to examine cardiovascular and autonomic function responses to isometric handgrip (IHG) exercise between men and women with T2D, before and after an exercise training program. Hemodynamic responses were measured in 22 men and women with T2D during and following a 3-minute IHG test, and before and after 16 wks of aerobic exercise training. Women had a smaller decrease in mean arterial pressure (MAP) and systolic blood pressure (BP) during recovery from IHG (ΔMAPREC) than men pre- and post-training (P<0.05). Men showed a greater reduction in diastolic BP during recovery from IHG (P<0.05), and exercise training improved this response in men but not in women (men, pre-training: −13.9±1.8, post-training: −20.5±5.3 mmHg vs. women, pre-training: −10.7±1.7, post-training: −4.1±4.9 mmHg; P<0.05). Men had a greater reduction in sympathetic modulation of vasomotor tone (P<0.05), as estimated by blood pressure variability, following IHG. This response was accentuated after training, while this training effect was not seen in women. Post-training ΔMAPREC was correlated with recovery of low frequency component of the BP spectrum (ΔLFSBPrec, r=0.52, P<0.05). Differences in BP recovery immediately following IHG may be attributed to gender differences in cardiovascular autonomic modulation. An improvement in these responses occurs following aerobic exercise training in obese men, but not in obese women with T2D which reflects a better adaptive autonomic response to exercise training.
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影响因子：
2.8
作者：
HUIKURI, HV;LINNALUOTO, MK;MYERBURG, RJ
通讯作者：
MYERBURG, RJ
影响因子：
--
作者：
AKSELROD, S;GORDON, D;COHEN, RJ
通讯作者：
COHEN, RJ
DOI：
10.1152/ajpheart.1996.270.1.h350
发表时间：
1996-01-01
影响因子：
4.8
作者：
Jones, PP;Spraul, M;Ravussin, E
通讯作者：
Ravussin, E
DOI：
10.1046/j.1365-201x.1997.00158.x
发表时间：
1997-07-01
期刊：
ACTA PHYSIOLOGICA SCANDINAVICA
影响因子：
--
作者：
Kagaya, A;Homma, S
通讯作者：
Homma, S
影响因子：
5.8
作者：
Franklin, Ruth M.;Baynard, Tracy;Kanaley, Jill A.
通讯作者：
Kanaley, Jill A.