The mouse "xenotropic" gammaretroviruses and their XPR1 receptor.
The mouse "xenotropic" gammaretroviruses and their XPR1 receptor.
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小鼠“异形”伽马甲病毒及其XPR1受体。
DOI：
10.1186/1742-4690-7-101
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发表时间：
2010-11-30
期刊：
影响因子：
3.3
通讯作者：
Kozak CA
中科院分区：
文献类型：
--
作者：
Kozak CA
小鼠白血病病毒（MLV）的异嗜性/多嗜性亚群都依赖于XPR 1受体进入，但这些病毒在嗜性、野生小鼠和实验室小鼠中的分布、致病性、用于传播的策略以及对宿主限制因子的敏感性方面各不相同。大多数（但不是全部）分离株具有典型的异嗜性或多变性宿主范围，这两种MLV嗜性类型现已在人体中作为病毒序列或感染性病毒（称为XMRV或异嗜性小鼠白血病病毒相关病毒）检测到。小鼠异嗜性MLV（X-MLV）最初被定义为它们不能感染其天然小鼠宿主的细胞。然而，现在很清楚，X-MLV实际上具有MLV中最广泛的主机范围。几乎所有非啮齿类哺乳动物都对X-MLV易感，所有野生小鼠和几种常见的实验室小鼠品系都对X-MLV易感。多变性MLV因其明显的广泛宿主范围而命名，显示出比X-MLV更有限的宿主范围，因为它们不能感染许多小鼠物种以及许多非啮齿类哺乳动物的细胞。这些病毒与其受体和影响其复制的其他宿主因子的共同进化产生了一组能够诱导各种疾病的异质性病毒，以及内源性病毒基因组，其中一些已被其宿主驯化以用于抗病毒防御。
The xenotropic/polytropic subgroup of mouse leukemia viruses (MLVs) all rely on the XPR1 receptor for entry, but these viruses vary in tropism, distribution among wild and laboratory mice, pathogenicity, strategies used for transmission, and sensitivity to host restriction factors. Most, but not all, isolates have typical xenotropic or polytropic host range, and these two MLV tropism types have now been detected in humans as viral sequences or as infectious virus, termed XMRV, or xenotropic murine leukemia virus-related virus. The mouse xenotropic MLVs (X-MLVs) were originally defined by their inability to infect cells of their natural mouse hosts. It is now clear, however, that X-MLVs actually have the broadest host range of the MLVs. Nearly all nonrodent mammals are susceptible to X-MLVs, and all species of wild mice and several common strains of laboratory mice are X-MLV susceptible. The polytropic MLVs, named for their apparent broad host range, show a more limited host range than the X-MLVs in that they fail to infect cells of many mouse species as well as many nonrodent mammals. The co-evolution of these viruses with their receptor and other host factors that affect their replication has produced a heterogeneous group of viruses capable of inducing various diseases, as well as endogenized viral genomes, some of which have been domesticated by their hosts to serve in antiviral defense.
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影响因子：
56.9
作者：
AARONSON, SA;TODARO, GJ;SCOLNICK, EM
通讯作者：
SCOLNICK, EM
影响因子：
64.8
作者：
Best, S;LeTissier, P;Stoye, JP
通讯作者：
Stoye, JP
影响因子：
5.4
作者：
CHATTOPADHYAY, SK;OLIFF, AI;LOWY, DR
通讯作者：
LOWY, DR
影响因子：
3.7
作者：
CLOYD, MW;THOMPSON, MM;HARTLEY, JW
通讯作者：
HARTLEY, JW
DOI：
10.1073/pnas.76.1.425
发表时间：
1979-01-01
影响因子：
11.1
作者：
CHESEBRO, B;WEHRLY, K
通讯作者：
WEHRLY, K