Geographic variation in the aetiology, epidemiology and microbiology of bronchiectasis.
Geographic variation in the aetiology, epidemiology and microbiology of bronchiectasis.
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DOI：
10.1186/s12890-018-0638-0
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发表时间：
2018-05-22
影响因子：
3.1
通讯作者：
Chotirmall SH
中科院分区：
文献类型：
--
作者：
Chandrasekaran R;Mac Aogáin M;Chalmers JD;Elborn SJ;Chotirmall SH
支气管扩张是一种与支气管慢性进行性和不可逆扩张相关的疾病，其特征是慢性感染和相关炎症。支气管扩张的患病率与年龄有关，并且发病率、患病率和临床特征存在一些地域差异。据报道，大多数支气管扩张是特发性的，但感染后病因在整个亚洲占主导地位，尤其是继发于结核病。迄今为止，最关注的焦点是气道细菌的研究，它们既是定植菌，又是病情加重的原因。包括下一代测序 (NGS) 在内的现代分子技术已成为直接从痰中识别微生物的宝贵工具，而使用传统的基于琼脂的方法很难培养这些微生物。这些为我们了解支气管扩张患者气道中新出现的病原体以及所发生的地理差异提供了重要的见解。肺微生物组的贡献、其种族差异以及随后在疾病进展和跨地理区域治疗反应中的作用值得进一步研究。本综述总结了支气管扩张的病因学、流行病学和微生物学方面已知的地理差异。此外，我们强调了新兴分子技术（例如组学）提供的机会，以进一步剖析支气管扩张的预后和治疗中的重要种族差异。
Bronchiectasis is a disease associated with chronic progressive and irreversible dilatation of the bronchi and is characterised by chronic infection and associated inflammation. The prevalence of bronchiectasis is age-related and there is some geographical variation in incidence, prevalence and clinical features. Most bronchiectasis is reported to be idiopathic however post-infectious aetiologies dominate across Asia especially secondary to tuberculosis. Most focus to date has been on the study of airway bacteria, both as colonisers and causes of exacerbations. Modern molecular technologies including next generation sequencing (NGS) have become invaluable tools to identify microorganisms directly from sputum and which are difficult to culture using traditional agar based methods. These have provided important insight into our understanding of emerging pathogens in the airways of people with bronchiectasis and the geographical differences that occur. The contribution of the lung microbiome, its ethnic variation, and subsequent roles in disease progression and response to therapy across geographic regions warrant further investigation. This review summarises the known geographical differences in the aetiology, epidemiology and microbiology of bronchiectasis. Further, we highlight the opportunities offered by emerging molecular technologies such as -omics to further dissect out important ethnic differences in the prognosis and management of bronchiectasis.
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影响因子：
3.7
作者：
Buscot, Matthieu;Pottier, Heloise;Leroy, Sylvie
通讯作者：
Leroy, Sylvie
DOI：
10.1164/ajrccm.151.1.7812549
发表时间：
1995-01-01
影响因子：
24.7
作者：
BATEMAN, ED;HAYASHI, S;HOGG, JC
通讯作者：
HOGG, JC
影响因子：
--
作者：
Bonaiti G;Pesci A;Marruchella A;Lapadula G;Gori A;Aliberti S
通讯作者：
Aliberti S
影响因子：
3.4
作者：
BECROFT, DMO
通讯作者：
BECROFT, DMO
DOI：
10.1098/rstb.2009.0137
发表时间：
2009-10-27
期刊：
Philosophical transactions of the Royal Society of London. Series B, Biological sciences
影响因子：
--
作者：
Bongaarts J
通讯作者：
Bongaarts J