Social opportunity rapidly regulates expression of CRF and CRF receptors in the brain during social ascent of a teleost fish, Astatotilapia burtoni.
Social opportunity rapidly regulates expression of CRF and CRF receptors in the brain during social ascent of a teleost fish, Astatotilapia burtoni.
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DOI：
10.1371/journal.pone.0096632
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Fernald RD
中科院分区：
文献类型：
--
作者：
Carpenter RE;Maruska KP;Becker L;Fernald RD
在群居动物中，等级制度决定着食物的可获得性、领土权利和繁殖机会。排名顺序可以快速变化，通常取决于动态的积极互动。由于神经调节剂促肾上腺皮质激素释放因子（CRF）整合了内部和外部的线索，以调节下丘脑-垂体肾上腺（HPA）轴，我们分析了CRF系统在社会交往中的地位。我们使用了一个特别合适的动物模型，非洲慈鲷鱼，Astatotilapia burtoni，其社会地位调节繁殖。当有机会晋升时，下属A。burtoni雄鱼迅速改变颜色、行为和生理，以支持其作为占主导地位的繁殖活跃的鱼类的新角色。虽然促性腺激素释放激素（GnRH 1）的变化，关键的生殖分子演员，已被分析在社会上升，很少有人知道CRF和HPA轴在过渡期间的作用。我们通过实验让男性在社会地位上有所提升，在社会地位提升开始后15分钟，我们测量了血浆皮质醇和特定脑区CRF系统的变化。血浆皮质醇水平在上升的鱼低于下属同种，但类似于占主导地位的动物的水平。在视前区（POA），其中GnRH 1细胞的位置，并在垂体，CRF和CRF 1受体mRNA水平迅速下调，在上升的男性相比，下属。在Vc/VI，一个前脑区CRF细胞体位于，mRNA编码CRFR 1和CRFR 2受体是较低的上升鱼相比，稳定的下属同种。这些变化的快速时间过程（在几分钟内）表明，CRF系统参与了与社会地位变化相关的生理变化。由于CRF通常对脊椎动物的神经内分泌生殖轴具有抑制作用，因此CRF活性的这种减弱可能允许生殖轴的快速激活并促进向优势的过渡。
In social animals, hierarchical rank governs food availability, territorial rights and breeding access. Rank order can change rapidly and typically depends on dynamic aggressive interactions. Since the neuromodulator corticotrophin releasing factor (CRF) integrates internal and external cues to regulate the hypothalamic-pituitary adrenal (HPA) axis, we analyzed the CRF system during social encounters related to status. We used a particularly suitable animal model, African cichlid fish, Astatotilapia burtoni, whose social status regulates reproduction. When presented with an opportunity to rise in rank, subordinate A. burtoni males rapidly change coloration, behavior, and their physiology to support a new role as dominant, reproductively active fish. Although changes in gonadotropin-releasing hormone (GnRH1), the key reproductive molecular actor, have been analyzed during social ascent, little is known about the roles of CRF and the HPA axis during transitions. Experimentally enabling males to ascend in social rank, we measured changes in plasma cortisol and the CRF system in specific brain regions 15 minutes after onset of social ascent. Plasma cortisol levels in ascending fish were lower than subordinate conspecifics, but similar to levels in dominant animals. In the preoptic area (POA), where GnRH1 cells are located, and in the pituitary gland, CRF and CRF1 receptor mRNA levels are rapidly down regulated in ascending males compared to subordinates. In the Vc/Vl, a forebrain region where CRF cell bodies are located, mRNA coding for both CRFR1 and CRFR2 receptors is lower in ascending fish compared to stable subordinate conspecifics. The rapid time course of these changes (within minutes) suggests that the CRF system is involved in the physiological changes associated with shifts in social status. Since CRF typically has inhibitory effects on the neuroendocrine reproductive axis in vertebrates, this attenuation of CRF activity may allow rapid activation of the reproductive axis and facilitate the transition to dominance.
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影响因子：
3.4
作者：
Cooper, Matthew A.;Huhman, Kim L.
通讯作者：
Huhman, Kim L.
影响因子：
4
作者：
Doyon, C;Trudeau, VL;Moon, TW
通讯作者：
Moon, TW
影响因子：
1.7
作者：
Bushnik, TL;Fernald, RD
通讯作者：
Fernald, RD
DOI：
10.1002/neu.480210804
发表时间：
1990-12-01
期刊：
JOURNAL OF NEUROBIOLOGY
影响因子：
--
作者：
DAVIS, MR;FERNALD, RD
通讯作者：
FERNALD, RD
影响因子：
3.5
作者：
Clements, S;Moore, FL;Schreck, CB
通讯作者：
Schreck, CB