Endocrine Disruptor Potential of Short- and Long-Chain Perfluoroalkyl Substances (PFASs)-A Synthesis of Current Knowledge with Proposal of Molecular Mechanism.
Endocrine Disruptor Potential of Short- and Long-Chain Perfluoroalkyl Substances (PFASs)-A Synthesis of Current Knowledge with Proposal of Molecular Mechanism.
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DOI：
10.3390/ijms22042148
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发表时间：
2021-02-21
影响因子：
5.6
通讯作者：
Mokra K
中科院分区：
文献类型：
--
作者：
Mokra K
内分泌干扰物是一组化合物，即使在低浓度下，也会导致体内激素失衡，导致各种有害健康疾病的发展。许多工业化合物由于其重要的商业价值和众多的应用而在全球范围内生产，但其内分泌作用的机制尚未完全了解。近年来，全氟烷基和多氟烷基物质（PFASs）引起了主要国际卫生组织的兴趣，因此越来越多的研究旨在解释这些化合物的毒性。PFASs最早于20世纪50年代合成，并广泛应用于消防剂，化妆品和除草剂的生产。全氟辛烷磺酸的众多工业应用，加上这些物质在人体内的半衰期特别长，而且在环境中具有极端持久性，导致普通民众普遍和长期接触到这些物质。现有数据表明，人类在不同发育阶段可能接触全氟辛烷磺酸，并可能造成短期或/和长期健康影响。本文综合了目前关于选定的长链和短链全氟辛烷磺酸的存在、生物累积性，特别是内分泌毒性的文献报告，特别强调了其内分泌作用的机制。
Endocrine disruptors are a group of chemical compounds that, even in low concentrations, cause a hormonal imbalance in the body, contributing to the development of various harmful health disorders. Many industry compounds, due to their important commercial value and numerous applications, are produced on a global scale, while the mechanism of their endocrine action has not been fully understood. In recent years, per- and polyfluoroalkyl substances (PFASs) have gained the interest of major international health organizations, and thus more and more studies have been aimed to explain the toxicity of these compounds. PFASs were firstly synthesized in the 1950s and broadly used in the industry in the production of firefighting agents, cosmetics and herbicides. The numerous industrial applications of PFASs, combined with the exceptionally long half-life of these substances in the human body and extreme environmental persistence, result in a common and chronic exposure of the general population to their action. Available data have suggested that human exposure to PFASs can occur during different stages of development and may cause short- or/and long-term health effects. This paper synthetizes the current literature reports on the presence, bioaccumulation and, particularly, endocrine toxicity of selected long- and short-chain PFASs, with a special emphasis on the mechanisms underlying their endocrine actions.
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Fernald 社区队列中纵向血清全氟烷基物质 (PFAS) 水平与甲状腺激素、肾功能和体重指数测量之间的关联。
DOI：
10.1016/j.envpol.2018.07.042
发表时间：
2018-11
期刊：
Environmental pollution (Barking, Essex : 1987)
影响因子：
--
作者：
Blake BE;Pinney SM;Hines EP;Fenton SE;Ferguson KK
通讯作者：
Ferguson KK
DOI：
10.1177/1073858413519865
发表时间：
2014-10
期刊：
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry
影响因子：
--
作者：
Bean LA;Ianov L;Foster TC
通讯作者：
Foster TC
影响因子：
11.8
作者：
Alderete, Tanya L.;Jin, Ran;Chatzi, Lida
通讯作者：
Chatzi, Lida
影响因子：
5
作者：
Andersen, Camilla Schou;Fei, Chunyuan;Olsen, Jorn
通讯作者：
Olsen, Jorn
影响因子：
11.4
作者：
Armitage, James M.;Schenker, Urs;Cousins, Ian T.
通讯作者：
Cousins, Ian T.