Solubility study of phytochemical cross-linking agents on dentin stiffness.
Solubility study of phytochemical cross-linking agents on dentin stiffness.
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DOI：
10.1016/j.jdent.2010.02.002
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发表时间：
2010-05
影响因子：
4.4
通讯作者：
Bedran-Russo, Ana Karina
中科院分区：
文献类型：
--
作者：
Castellan, Carina Strano;Pereira, Patricia N. R.;Viana, Grace;Chen, Shao-Nong;Pauli, Guido F.;Bedran-Russo, Ana Karina
研究了极性溶剂中的交联型原花青素(PA)与脱矿牙本质中I型胶原的相互作用。三种富含PA的提取物，两种来自葡萄籽(GSEP和GSES)，一种来自可可(COE)，被溶解(水、乙醇：水和丙酮：水)，并分析它们增加脱矿牙本质弹性模量的能力。声学牙本质束(0.5×1.7×7 mm)完全脱矿，根据所用交联剂和溶剂的类型分为12组。将样品浸入各自的溶液中，并在基线、10、30、60、120和240分钟进行测试。PA处理后，牙本质的弹性模量值(EM)在不同时间均显著增加(p<；0.05)。提取物在不同的溶剂中表现出不同的溶解度。在所有暴露时间内，GSEP在蒸馏水和丙酮中稀释时的EM增加幅度最大。两种GSE在蒸馏水中稀释和处理4h后均表现出较好的效果，而CoE在乙醇：水中溶解时的促进作用最强。结果表明，中草药提取工艺和其他生药学参数对提取液的溶解度和成分有重要影响，从而影响PA-牙本质基质的相互作用。
The effects of interactions between cross-linking proanthocyanidins (PA) in polar solvents and type-I collagen of demineralized dentin was investigated. Three PA-rich extracts, two from grape seed (GSEP and GSES) and one from cocoa (COE), were dissolved (water, ethanol:water and acetone:water) and analyzed for their ability to increase the modulus of elasticity of demineralized dentin. Sound dentin beams (0.5 X 1.7 X 7 mm) were fully demineralized and divided into 12 groups according to the type of cross-linking agent and solvents used. Specimens were immersed in the respective solutions and tested at baseline, 10, 30, 60, 120 and 240 min. The elastic modulus (EM) of dentin was significantly increased by the PA treatment regardless of time (p<0.05 for all times). The extracts showed different solubility in different solvents. GSEP showed the highest increase in EM when diluted in distilled water and acetone at all exposure times. Both GSEs showed superior results when diluted in distilled water and after 4 hours of treatment, while COE produced strongest enhancement when dissolved in ethanol:water. The results indicates that herbal extraction process and other pharmacognostic parameters have an important influence on extract solubility as well as constitution and, consequently, on the PA-dentin matrix interaction.
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影响因子：
3.5
作者：
LIGHT, ND;BAILEY, AJ
通讯作者：
BAILEY, AJ
影响因子：
2.4
作者：
Shi, John;Yu, Jianmel;Kakuda, Yukio
通讯作者：
Kakuda, Yukio
DOI：
10.1002/jmb.b.31022
发表时间：
2008-08-01
影响因子：
3.4
作者：
Bedran-Russo, Ana Karina B.;Pashley, David H.;Miescke, Klaus J.
通讯作者：
Miescke, Klaus J.
影响因子：
2.9
作者：
Butler, W T
通讯作者：
Butler, W T
影响因子：
14
作者：
Charulatha, V;Rajaram, A
通讯作者：
Rajaram, A