Reliability of transcallosal inhibition measurements for the lower limb motor cortex in stroke.
Reliability of transcallosal inhibition measurements for the lower limb motor cortex in stroke.
复制标题
中风下肢运动皮层经胼胝体抑制测量的可靠性。
DOI：
10.1016/j.neulet.2020.135558
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发表时间：
2021-01-19
影响因子：
2.5
通讯作者：
Madhavan S
中科院分区：
文献类型：
--
作者：
Sivaramakrishnan A;Madhavan S
经胼胝体抑制（TCI）是一种衡量半球间抑制控制的指标，可通过同侧静息期（iSP）经颅磁刺激（TMS）范式进行评估。对下肢iSP的研究可能由于下肢运动表征的紧密定位而受到限制。TCI的变化可以为中风时皮质运动兴奋性不对称的病理生理机制提供见解。在此，我们描述了一种iSP量化方法，并报告了中风患者胫前肌（TA）iSP参数的可靠性。26名中风患者参加了三次实验，在实验中使用单脉冲TMS测量从病变半球到非病变半球的TCI。使用双锥线圈刺激同侧运动皮层，同时参与者保持非瘫痪侧胫前肌的等长收缩。计算了iSP潜伏期、持续时间和面积的绝对和相对可靠性。iSP潜伏期显示出最低的测量误差（绝对可靠性），并且iSP潜伏期、持续时间和面积显示出良好的相对可靠性（组内相关系数>0.6）。这项研究表明，胫前肌的iSP参数是可靠的，并试图为评估中风及其他临床人群的下肢TCI提供指导。
Transcallosal inhibition (TCI) is a measure of between-hemisphere inhibitory control that can be evaluated with the ipsilateral silent period (iSP) transcranial magnetic stimulation (TMS) paradigm. The study of iSP for the lower extremity has been limited possibly due to the close orientation of the lower extremity motor representations. Change in TCI can provide insights into pathophysiological mechanisms underlying the asymmetry in corticomotor excitability in stroke. Here, we describe a method for iSP quantification and report reliability of iSP parameters for the tibialis anterior (TA) muscle in stroke. 26 individuals with stroke attended three sessions where single pulse TMS was used to measure TCI from the lesioned to non-lesioned hemisphere. A double cone coil was used for stimulating the ipsilateral motor cortex while the participant maintained an isometric contraction of the non-paretic TA. Absolute and relative reliability were computed for iSP latency, duration and area. iSP latency showed the lowest measurement error (absolute reliability) and iSP latency, duration and area showed good relative reliability (intraclass correlation coefficients > 0.6). This study suggests that iSP parameters for the tibialis anterior are reliable and attempts to provide a guideline for evaluating TCI for the lower extremity in stroke and other clinical populations.
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