Rhythmic TMS causes local entrainment of natural oscillatory signatures.
Rhythmic TMS causes local entrainment of natural oscillatory signatures.
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DOI：
10.1016/j.cub.2011.05.049
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发表时间：
2011-07-26
期刊：
影响因子：
9.2
通讯作者：
Gross, Joachim
中科院分区：
文献类型：
--
作者：
Thut, Gregor;Veniero, Domenica;Romei, Vincenzo;Miniussi, Carlo;Schyns, Philippe;Gross, Joachim
感知、认知和动作的神经元元件表现出独特的振荡现象，在人类中通过脑电图或脑磁图（EEG/MEG）进行测量。到目前为止，脑振荡和功能之间的相关性或因果关系仍然难以捉摸。一个令人信服的因果关系证明将主要产生振荡信号，已知与特定的认知功能相关，然后评估行为后果。在这里，我们提供了第一个直接的证据，因果夹带的脑振荡经颅磁刺激（TMS）使用并发脑电图。我们使用有节奏的经颅磁刺激脉冲直接与脑磁图识别的顶叶α振荡器相互作用，该振荡器由注意力激活并与感知相关。将TMS爆发调谐到其首选α频率（α-TMS），我们证实了自然振荡器夹带的三个主要预测：（1）在α-TMS过程中诱发α-振荡（再现受刺激顶叶皮层的振荡信号），（2）这种α-活性逐渐增强（使目标α发生器与α-TMS序列同步），以及（3）这取决于背景α节律的前TMS阶段（自然持续α振荡的夹带）。在体模头部中测试不同TMS爆发轮廓和TMS-EEG的控制条件证实了α增强对TMS训练和神经振荡器之间同步情况的特异性。在有节奏的TMS过程中产生的周期性电磁力可以引起自然脑振荡的局部夹带，模拟由认知任务激活的振荡签名。这揭示了在线TMS对大脑活动的作用的新机制，并且可以在生物相关节律的水平上解释频率特异性行为TMS效应。有节奏的TMS爆发驱动潜在的大脑节律这会产生特定频率和特定部位的振荡活动模式增强的节律再现自然的大脑振荡TMS对大脑活动和行为的作用的新机制已经被揭示
Neuronal elements underlying perception, cognition, and action exhibit distinct oscillatory phenomena, measured in humans by electro- or magnetoencephalography (EEG/MEG). So far, the correlative or causal nature of the link between brain oscillations and functions has remained elusive. A compelling demonstration of causality would primarily generate oscillatory signatures that are known to correlate with particular cognitive functions and then assess the behavioral consequences. Here, we provide the first direct evidence for causal entrainment of brain oscillations by transcranial magnetic stimulation (TMS) using concurrent EEG. We used rhythmic TMS bursts to directly interact with an MEG-identified parietal α-oscillator, activated by attention and linked to perception. With TMS bursts tuned to its preferred α-frequency (α-TMS), we confirmed the three main predictions of entrainment of a natural oscillator: (1) that α-oscillations are induced during α-TMS (reproducing an oscillatory signature of the stimulated parietal cortex), (2) that there is progressive enhancement of this α-activity (synchronizing the targeted, α-generator to the α-TMS train), and (3) that this depends on the pre-TMS phase of the background α-rhythm (entrainment of natural, ongoing α-oscillations). Control conditions testing different TMS burst profiles and TMS-EEG in a phantom head confirmed specificity of α-boosting to the case of synchronization between TMS train and neural oscillator. The periodic electromagnetic force that is generated during rhythmic TMS can cause local entrainment of natural brain oscillations, emulating oscillatory signatures activated by cognitive tasks. This reveals a new mechanism of online TMS action on brain activity and can account for frequency-specific behavioral TMS effects at the level of biologically relevant rhythms. ► Rhythmic TMS bursts drive underlying brain rhythms ► This generates frequency- and site-specific patterns of oscillatory activity ► The enhanced rhythms reproduce natural brain oscillations ► A new mechanism of TMS action on brain activity and behavior has been revealed
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影响因子：
2.7
作者：
Johnson, Jeffrey S.;Hamidi, Massihullah;Postle, Bradley R.
通讯作者：
Postle, Bradley R.
影响因子：
3.8
作者：
Feurra M;Paulus W;Walsh V;Kanai R
通讯作者：
Kanai R
影响因子：
5.7
作者：
Hanslmayr, Simon;Aslan, Alp;Baeuml, Karl-Heinz
通讯作者：
Baeuml, Karl-Heinz
影响因子：
3.4
作者：
Klimesch, W;Sauseng, P;Gerloff, C
通讯作者：
Gerloff, C
DOI：
10.1523/jneurosci.5252-09.2010
发表时间：
2010-08-25
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Ozen S;Sirota A;Belluscio MA;Anastassiou CA;Stark E;Koch C;Buzsáki G
通讯作者：
Buzsáki G