Lower GDNF Serum Level Is a Possible Risk Factor for Constipation in Patients With Parkinson Disease: A Case-Control Study.
Lower GDNF Serum Level Is a Possible Risk Factor for Constipation in Patients With Parkinson Disease: A Case-Control Study.
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DOI：
10.3389/fneur.2021.777591
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发表时间：
2021
影响因子：
3.4
通讯作者：
Dian-Shuai G
中科院分区：
文献类型：
--
作者：
Chen G;Du Y;Li X;Kambey PA;Wang L;Xia Y;Tang C;Shi M;Zai-Li L;Zai-E X;Xiao-Ling Q;Dian-Shuai G
背景：惊厥是帕金森病（PD）的一个重要症状。胶质源性神经营养因子（GDNF）对肠神经系统的形态发生非常重要，在肠胶质细胞的监视下，在保护粘膜完整性方面起着关键作用。本研究的目的是评价PD伴和不伴便秘患者血清GDNF水平。方法：对128例帕金森病患者进行研究。将患者分为三组：PD但无便秘的患者（n = 49）、前驱期便秘的患者（n = 48）和临床期便秘的患者（n = 31）。采用逻辑回归分析探讨血清GDNF浓度与便秘的关系。结果如下：nCons-PD组的平均GDNF水平为528.44 pg/ml，高于Cons-Pro-PD组的360.72 pg/ml和Cons-Clinic-PD组的331.36 pg/ml。二元Logistic回归分析结果显示GDNF是预防便秘的保护性因素。与nCons-PD组相比，Cons-Clinic-PD组的MDS-MRS-II、MDS-MRS-III、MDS-MRS-IV评分较高，H-Y分期较高。相对于nCons-PD组，Cons-Clinic-PD的NMSS评分较高，莫卡和PDSS评分较低，并且更有可能患有RBD。结论：便秘型PD患者血清GDNF水平较低。低GDNF水平是PD患者便秘的潜在危险因素。
Background: Constipation is a significant symptom of Parkinson's disease (PD). Glial-derived neurotrophic factor (GDNF) is important for the morphogenesis of the enteric nervous system and plays a critical role in the preservation of mucosal integrity under enteric glia surveillance. The aim of this work was to evaluate the serum levels of GDNF in patients with PD with and without constipation. Methods: This work included 128 patients with PD. The patients were classified into three groups: those with PD but no constipation (nCons-PD) (n = 49), those with prodromal stage constipation (Cons-Pro-PD) (n = 48), and those with clinical stage constipation (Cons-Clinic-PD) (n = 31). The association between serum GDNF concentration and constipation was explored using logical regression. Results: The nCons-PD group's mean GDNF levels were 528.44 pg/ml, which was higher than the Cons-Pro-PD group's 360.72 pg/ml and the Cons-Clinic-PD group's 331.36 pg/ml. The results of binary logistic regression indicated that GDNF was a protective factor in the prevention of constipation. Cons-Clinic-PD group had a higher score of MDS-UPDRS-II, MDS-UPDRS-III, MDS-UPDRS-IV, and a higher H-Y staging as compared with nCons-PD group. Relative to the nCons-PD group, Cons-Clinic-PD had higher NMSS scores, lower MoCA and PDSS scores, and were more likely to have RBD. Conclusions: GDNF serum levels are lower in patients with PD who are constipated. A low GDNF level is a potential risk factor for constipation in patients with PD.
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DOI：
10.1002/mds.28312
发表时间：
2021-01
期刊：
Movement disorders : official journal of the Movement Disorder Society
影响因子：
--
作者：
Iwaki H;Blauwendraat C;Leonard HL;Makarious MB;Kim JJ;Liu G;Maple-Grødem J;Corvol JC;Pihlstrøm L;van Nimwegen M;Smolensky L;Amondikar N;Hutten SJ;Frasier M;Nguyen KH;Rick J;Eberly S;Faghri F;Auinger P;Scott KM;Wijeyekoon R;Van Deerlin VM;Hernandez DG;Gibbs RJ;Day-Williams AG;Brice A;Alves G;Noyce AJ;Tysnes OB;Evans JR;Breen DP;Estrada K;Wegel CE;Danjou F;Simon DK;Andreassen OA;Ravina B;Toft M;Heutink P;Bloem BR;Weintraub D;Barker RA;Williams-Gray CH;van de Warrenburg BP;Van Hilten JJ;Scherzer CR;Singleton AB;Nalls MA
通讯作者：
Nalls MA
影响因子：
11
作者：
HUGHES, AJ;DANIEL, SE;LEES, AJ
通讯作者：
LEES, AJ
影响因子：
5.2
作者：
Makaroff, Lydia;Gunn, Angus;Richy, Florent
通讯作者：
Richy, Florent
影响因子：
8.6
作者：
Pont-Sunyer, Claustre;Hotter, Anna;Tolosa, Eduardo
通讯作者：
Tolosa, Eduardo
影响因子：
5.2
作者：
Knudsen, Karoline;Fedorova, Tatyana D.;Borghammer, Per
通讯作者：
Borghammer, Per