FoxP2 Expression in a Highly Vocal Teleost Fish with Comparisons to Tetrapods

FoxP2 Expression in a Highly Vocal Teleost Fish with Comparisons to Tetrapods
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FoxP2 在高声硬骨鱼中的表达与四足动物的比较

DOI:
10.1159/000487793
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发表时间:
2018
期刊:
Behavior and Evolution
影响因子:
--
通讯作者:
Bass, Andrew H.
Bass, Andrew H.
中科院分区:
--
文献类型:
--
作者:
Pengra, Ian G.G.;Marchaterre, Margaret A.;Bass, Andrew H.

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受人类言语缺陷研究的启发,过去二十年的多项研究探讨了叉头结构域转录因子FoxP 2在脊椎动物声音信号/发声中央控制中的潜在作用。主要包括哺乳动物和鸟类物种的比较神经解剖学研究已经绘制了FoxP 2表达在多个脑区的分布,这意味着除了发声之外还有更大的功能意义,这可能在脊椎动物谱系中广泛共享。到目前为止,硬骨鱼的报告在数量和范围上都局限于非发声物种。在这里,我们映射的神经解剖分布ofFoxP 2 mRNA的表达,在一个高度发声硬骨鱼,plainfin见习(Porichthys notatus)。我们报告了FoxP 2表达和声音,听觉和类固醇信号系统之间的广泛重叠,在端脑,视前区,间脑和中脑的多个位点具有强大的表达。尽管在网状结构的一个区域中标记是强有力的,但在后脑中的标记受到更多的限制。与其他硬骨鱼和四足动物的比较表明,进化保守的FoxP 2表型重要的声音,声学,更广泛地说,脊椎动物之间的感觉运动功能。
Motivated by studies of speech deficits in humans, several studies over the past two decades have investigated the potential role of a forkhead domain transcription factor, FoxP2, in the central control of acoustic signaling/vocalization among vertebrates. Comparative neuroanatomical studies that mainly include mammalian and avian species have mapped the distribution of FoxP2 expression in multiple brain regions that imply a greater functional significance beyond vocalization that might be shared broadly across vertebrate lineages. To date, reports for teleost fish have been limited in number and scope to nonvocal species. Here, we map the neuroanatomical distribution ofFoxP2mRNA expression in a highly vocal teleost, the plainfin midshipman (Porichthys notatus). We report an extensive overlap betweenFoxP2expression and vocal, auditory, and steroid-signaling systems with robust expression at multiple sites in the telencephalon, the preoptic area, the diencephalon, and the midbrain. Label was far more restricted in the hindbrain though robust in one region of the reticular formation. A comparison with other teleosts and tetrapods suggests an evolutionarily conserved FoxP2 phenotype important to vocal-acoustic and, more broadly, sensorimotor function among vertebrates.
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