The Effects of Hormonal Contraceptives on the Brain: A Systematic Review of Neuroimaging Studies.
The Effects of Hormonal Contraceptives on the Brain: A Systematic Review of Neuroimaging Studies.
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DOI：
10.3389/fpsyg.2020.556577
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发表时间：
2020
影响因子：
3.8
通讯作者：
Brønnick KK
中科院分区：
文献类型：
--
作者：
Brønnick MK;Økland I;Graugaard C;Brønnick KK
背景：激素类避孕药被全世界的成年和青春期妇女使用。来自动物研究的一致证据表明，避孕物质可以改变大脑的结构和功能，但这种影响并不是关于这些药物的公共话语或临床决策的一部分。因此，我们对神经影像学文献进行了系统回顾，以评估激素避孕药对人脑影响的现有证据。方法：在PROSPERO中注册，按照PRISMA系统评价标准进行评价。根据预先确定的选择标准进行全面和系统性检索后，纳入了截至2020年2月在Embase、PubMed和/或PsycINFO中索引的关于激素避孕药使用的结构和功能神经影像学研究。结果：共有33篇文章符合纳入标准。其中10项为结构研究，23项为功能研究。只有一项研究调查了对青少年样本的影响。文章的质量各不相同，因为许多文章存在方法上的挑战以及部分没有根据的理论主张。然而，大多数纳入的神经影像学研究发现与使用激素避孕药相关的功能和/或结构性大脑变化。结论：纳入的研究确定了与情感和认知处理有关的区域的结构和功能变化，如杏仁核、海马体、前额皮质和扣带回。然而，只有一项研究报告了对纯青少年样本的初步研究。因此，有必要进一步调查这些调查结果的影响，特别是对少女的影响。
Background: Hormonal contraceptive drugs are being used by adult and adolescent women all over the world. Convergent evidence from animal research indicates that contraceptive substances can alter both structure and function of the brain, yet such effects are not part of the public discourse or clinical decision-making concerning these drugs. We thus conducted a systematic review of the neuroimaging literature to assess the current evidence of hormonal contraceptive influence on the human brain. Methods: The review was registered in PROSPERO and conducted in accordance with the PRISMA criteria for systematic reviews. Structural and functional neuroimaging studies concerning the use of hormonal contraceptives, indexed in Embase, PubMed and/or PsycINFO until February 2020 were included, following a comprehensive and systematic search based on predetermined selection criteria. Results: A total of 33 articles met the inclusion criteria. Ten of these were structural studies, while 23 were functional investigations. Only one study investigated effects on an adolescent sample. The quality of the articles varied as many had methodological challenges as well as partially unfounded theoretical claims. However, most of the included neuroimaging studies found functional and/or structural brain changes associated with the use of hormonal contraceptives. Conclusion: The included studies identified structural and functional changes in areas involved in affective and cognitive processing, such as the amygdala, hippocampus, prefrontal cortex and cingulate gyrus. However, only one study reported primary research on a purely adolescent sample. Thus, there is a need for further investigation of the implications of these findings, especially with regard to adolescent girls.
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DOI：
10.1186/1755-7682-3-24
发表时间：
2010-10-06
期刊：
International archives of medicine
影响因子：
--
作者：
Arias-Carrión O;Stamelou M;Murillo-Rodríguez E;Menéndez-González M;Pöppel E
通讯作者：
Pöppel E
DOI：
10.1016/j.beem.2012.11.004
发表时间：
2013-02-01
影响因子：
7.4
作者：
Christin-Maitre, Sophie
通讯作者：
Christin-Maitre, Sophie
影响因子：
3.5
作者：
Beltz, Adriene M.;Berenbaum, Sheri A.
通讯作者：
Berenbaum, Sheri A.
影响因子：
2.9
作者：
Forsman, Lea J.;de Manzano, Orjan;Ullen, Fredrik
通讯作者：
Ullen, Fredrik
影响因子：
5.8
作者：
Arnoni-Bauer, Yardena;Bick, Atira;Weiss, Ram
通讯作者：
Weiss, Ram