Mapping hV4 and ventral occipital cortex: the venous eclipse.

Mapping hV4 and ventral occipital cortex: the venous eclipse.
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DOI:
10.1167/10.5.1
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发表时间:
2010-05-01
期刊:
影响因子:
1.8
通讯作者:
Wandell BA
Wandell BA
中科院分区:
医学4区
文献类型:
--
作者:
Winawer J;Horiguchi H;Sayres RA;Amano K;Wandell BA

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虽然第四人类视野图(hV4)已经研究了二十年,但其空间组织仍然存在不确定性。在分析旨在解决这些问题的fMRI测量结果时,我们发现了一个严重的问题,即腹侧枕叶皮质的测量结果,特别是hV4附近的测量结果。在大多数半球中,fMRI hV4数据受到横窦(TS)伪影的污染。我们创建了一个模型的TS伪影,并表明该模型预测的位置异常的功能磁共振成像反应简单的大场开关刺激。在许多受试者中,特别是左半球,TS伪影掩盖了功能磁共振成像反应,特别是在区分两个主要的hV4模型的皮层区域。通过选择TS从hV4的外侧边缘移位的受试者,我们能够看到静脉周围。在这些受试者中,视野覆盖范围延伸到下子午线,或几乎如此,与hV4位于腹侧表面并响应整个对侧半野的信号的模型一致。
While the fourth human visual field map (hV4) has been studied for two decades, there remain uncertainties about its spatial organization. In analyzing fMRI measurements designed to resolve these issues, we discovered a significant problem that afflicts measurements from ventral occipital cortex, and particularly measurements near hV4. In most hemispheres the fMRI hV4 data are contaminated by artifacts from the transverse sinus (TS). We created a model of the TS artifact and showed that the model predicts the locations of anomalous fMRI responses to simple large-field on–off stimuli. In many subjects, and particularly the left hemisphere, the TS artifact masks fMRI responses specifically in the region of cortex that distinguishes the two main hV4 models. By selecting subjects with a TS displaced from the lateral edge of hV4, we were able to see around the vein. In these subjects, the visual field coverage extends to the lower meridian, or nearly so, consistent with a model in which hV4 is located on the ventral surface and responds to signals throughout the full contralateral hemifield.
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