Prenatal exposure to environmental pollutants and child development trajectories through 7 years.
Prenatal exposure to environmental pollutants and child development trajectories through 7 years.
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DOI：
10.1016/j.ijheh.2018.04.004
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发表时间：
2018-05
影响因子：
6
通讯作者：
Ramakrishnan U
中科院分区：
文献类型：
--
作者：
Gonzalez-Casanova I;Stein AD;Barraza-Villarreal A;Feregrino RG;DiGirolamo A;Hernandez-Cadena L;Rivera JA;Romieu I;Ramakrishnan U
产前暴露于环境污染物，如霉菌，铅，杀虫剂，烟草和空气污染物已被认为会损害认知发育。需要从纵向研究中获得证据，以了解它们对儿童发展的共同影响。研究妊娠期暴露于室内环境污染物或室外空气污染与7年内后代认知发育轨迹之间的关系。我们包括718对墨西哥母子。产前暴露于室内环境污染物（霉菌，通风，农药，烟草烟雾，和使用vidiartred陶罐）的母亲自我报告，并整合到一个指数，或客观测量的情况下，室外空气污染物（氮氧化物，苯，甲苯，二甲苯）。儿童整体认知发育在12、18、60或84个月时进行测量。使用潜在类别增长分析，我们确定了三个发展轨迹（阳性=108，平均=362，低=248）。我们使用多项逻辑模型来测试环境污染物评分（EPS）或室外空气污染物与认知发展轨迹之间的关联。调整社会人口统计学协变量后，EPS与平均（OR=1.26，95%CI=1.01，1.55）和低（OR=1.41，95%CI=1.11，1.79）轨迹相比，积极的;其中EPS的单位增加意味着额外的产前暴露于污染物。室外空气污染物与认知发展轨迹之间没有关联。报告在怀孕期间暴露于室内环境污染物的妇女的孩子更有可能在7年内遵循更差的发育轨迹。这些结果支持开发和测试干预措施，以减少怀孕和幼儿期暴露于环境污染物，作为改善长期认知发展的潜在策略。
Prenatal exposure to environmental pollutants such as mold, lead, pesticides, tobacco, and air pollutants has been suggested to impair cognitive development. Evidence is needed from longitudinal studies to understand their joint impact on child development across time. To study associations between exposure to indoor environmental pollutants or outdoor air pollution during pregnancy and offspring cognitive development trajectories through 7 years. We included 718 Mexican mother-child pairs. Prenatal exposure to indoor environmental pollutants (mold, ventilation, pesticides, tobacco smoke, and use of vidiartred clay pots) was self-reported by the mothers and integrated into an index, or objectively measured in the case of outdoor air pollutants (nitrogen oxides, benzene, toluene, and xylene). Child global cognitive development was measured at 12, 18, 60, or 84 months. Using Latent Class Growth Analysis, we identified three developmental trajectories (positive=108, average=362, low=248). We used multinomial logistic models to test associations between environmental pollutant score (EPS) or outdoor air pollutants, and cognitive development trajectories. After adjustment for sociodemographic covariates, EPS was associated with the average (OR=1.26 95%CI=1.01, 1.55) and low (OR=1.41 95%CI=1.11, 1.79) trajectories compared to positive; where a unit increase in EPS means an additional prenatal exposure to a pollutant. There was no association between outdoor air pollutants and cognitive development trajectories. Children of women who reported higher exposure to indoor environmental pollutants during pregnancy were more likely to follow worse developmental trajectories through 7 years. These results support the development and testing of interventions to reduce exposure to environmental pollutants during pregnancy and early childhood as a potential strategy to improve long-term cognitive development.
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影响因子：
5
作者：
Morales, Eva;Julvez, Jordi;Sunyer, Jordi
通讯作者：
Sunyer, Jordi
DOI：
10.1037/h0020970
发表时间：
1965-01-01
期刊：
JOURNAL OF CONSULTING PSYCHOLOGY
影响因子：
--
作者：
CLEMENTS, GR
通讯作者：
CLEMENTS, GR
影响因子：
10.4
作者：
Chiu YH;Bellinger DC;Coull BA;Anderson S;Barber R;Wright RO;Wright RJ
通讯作者：
Wright RJ
影响因子：
5.4
作者：
Guxens, Monica;Garcia-Esteban, Raquel;Sunyer, Jordi
通讯作者：
Sunyer, Jordi
影响因子：
2.3
作者：
Hays, JR;Reas, DL;Shaw, JB
通讯作者：
Shaw, JB