An experimental demonstration that early-life competitive disadvantage accelerates telomere loss.
An experimental demonstration that early-life competitive disadvantage accelerates telomere loss.
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DOI：
10.1098/rspb.2014.1610
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发表时间：
2015-01-07
期刊：
影响因子：
--
通讯作者：
Bateson M
中科院分区：
文献类型：
--
作者：
Nettle D;Monaghan P;Gillespie R;Brilot B;Bedford T;Bateson M
生命早期的不良经历会对成年后的生存和健康产生巨大的延迟影响。端粒磨损是这种效应的潜在重要机制。早期生活逆境的一个来源是竞争劣势造成的压力。尽管先前的鸟类实验表明，竞争劣势可能加速端粒磨损，但它们并没有清楚地将竞争劣势的影响与其他变异来源隔离开来。在这里，我们展示了一项欧洲椋鸟（Sturnus vulgaris）实验的数据，该实验采用交叉培养的方法，让兄弟姐妹接触到不同的早期经历。在孵化后的第3天和第12天，将鸟类分为竞争优势组（比竞争对手大）和竞争劣势组（比竞争对手小）。不利条件不影响体重增加，但增加了端粒磨损，导致不利条件下12天的端粒长度变短。血浆脂质过氧化测定结果显示，不利条件对氧化损伤无影响。因此，我们发现了强有力的证据，证明生命早期的竞争劣势会加速端粒的损失。这可能会导致与年龄相关的疾病更快恶化，晚年的健康状况更差。
Adverse experiences in early life can exert powerful delayed effects on adult survival and health. Telomere attrition is a potentially important mechanism in such effects. One source of early-life adversity is the stress caused by competitive disadvantage. Although previous avian experiments suggest that competitive disadvantage may accelerate telomere attrition, they do not clearly isolate the effects of competitive disadvantage from other sources of variation. Here, we present data from an experiment in European starlings (Sturnus vulgaris) that used cross-fostering to expose siblings to divergent early experience. Birds were assigned either to competitive advantage (being larger than their brood competitors) or competitive disadvantage (being smaller than their brood competitors) between days 3 and 12 post-hatching. Disadvantage did not affect weight gain, but it increased telomere attrition, leading to shorter telomere length in disadvantaged birds by day 12. There were no effects of disadvantage on oxidative damage as measured by plasma lipid peroxidation. We thus found strong evidence that early-life competitive disadvantage can accelerate telomere loss. This could lead to faster age-related deterioration and poorer health in later life.
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DOI：
10.1098/rspb.2006.3546
发表时间：
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影响因子：
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