A global picture: therapeutic perspectives for COVID-19.
A global picture: therapeutic perspectives for COVID-19.
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DOI：
10.2217/imt-2021-0168
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发表时间：
2022-04
期刊：
影响因子：
2.8
通讯作者：
Apostolopoulos V
中科院分区：
文献类型：
--
作者：
Chavda VP;Kapadia C;Soni S;Prajapati R;Chauhan SC;Yallapu MM;Apostolopoulos V
COVID-19大流行是由严重急性呼吸系统综合征冠状病毒2型（SARS-CoV-2）引起的致命病毒爆发，严重影响了人类生活和全球经济。研发治疗药物的最重要部分是设计药物产品以有效管理COVID-19。已经进行了许多尝试来确定在全球范围内治疗该疾病的最佳药物剂量和药物组合。本文记录了SARS-CoV-2及其生命周期的可用信息，这将有助于开发潜在的治疗方案。本报告综合概述了几种用于管理COVID-19的天然药物和改性药物，并概述了目前的疫苗开发情况。高龄、合并症和伴随疾病（如超重、代谢紊乱、肺部疾病、冠心病、肾衰竭、脂肪肝和肿瘤性疾病）的人群更容易产生严重的COVID-19及其后果。本文还概述了患者的COVID-19后并发症。严重急性呼吸系统综合征冠状病毒-2引起冠状病毒疾病，即，2019冠状病毒病。本文包含有关冠状病毒和COVID-19的基本信息。它包括有关COVID-19在人体内的病毒传播和后续事件的信息，并介绍了用于管理COVID-19的不同药物和疫苗。几种天然药物被提议用于管理COVID-19。它还概述了康复患者的COVID-19后并发症。
The COVID-19 pandemic is a lethal virus outbreak by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), which has severely affected human lives and the global economy. The most vital part of the research and development of therapeutic agents is to design drug products to manage COVID-19 efficiently. Numerous attempts have been in place to determine the optimal drug dose and combination of drugs to treat the disease on a global scale. This article documents the information available on SARS-CoV-2 and its life cycle, which will aid in the development of the potential treatment options. A consolidated summary of several natural and repurposed drugs to manage COVID-19 is depicted with summary of current vaccine development. People with high age, comorbity and concomitant illnesses such as overweight, metabolic disorders, pulmonary disease, coronary heart disease, renal failure, fatty liver and neoplastic disorders are more prone to create serious COVID-19 and its consequences. This article also presents an overview of post-COVID-19 complications in patients. Severe acute respiratory syndrome coronavirus-2 causes the coronavirus disease i.e., COVID-19. This article encompasses basic information about coronavirus and COVID-19. It includes information about viral transmission and subsequent events for COVID-19 in a person, and it presents different drugs and vaccines utilized for the management of COVID-19. Several natural drugs are proposed to manage COVID-19. It also has an overview about post-COVID-19 complications in recovered patients.
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期刊：
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作者：
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