Darunavir ethanolate: Repurposing an anti-HIV drug in COVID-19 treatment.
Darunavir ethanolate: Repurposing an anti-HIV drug in COVID-19 treatment.
复制标题
DOI：
10.1016/j.ejmcr.2021.100013
复制
发表时间：
2021-12
期刊：
影响因子：
--
通讯作者：
Dave DJ
中科院分区：
文献类型：
--
作者：
Chavda VP;Gajjar N;Shah N;Dave DJ
市场上已经上市的抗病毒药物以及从 SARS 和 MERS 疫情中获得的专业知识正在成为对抗冠状病毒爆发的最有效方法。 SARS-CoV-2 由于呼吸衰竭而造成相当大的死亡率，这突出表明迫切需要成功的治疗方法，以及长期需要抗病毒药物来对抗潜在的冠状病毒突变体。由于世界正在经历不同的 SARS-CoV-2 浪潮，人们不断观察到病毒突变。如果我们对 COVID-19 的病毒学和临床表现的了解不断加深，可能的药理学靶点也会不断增加。在 COVID-19 中，正确分析当前临床前/临床数据以及创建有关药物重新利用的新证据的困难将至关重要。目前的手稿旨在通过计算机研究评估抗 HIV 药物乙醇达芦那韦 (Darunavir Ethanolate) 在 COVID-19 治疗中的重新利用，我们讨论了乙醇达芦那韦 (Darunavir Etanolate) 预防 SARS-CoV-2 复制的治疗进展，这支持了其对 COVID-19 治疗的临床评估。
Antivirals already on the market and expertise gained from the SARS and MERS outbreaks are gaining momentum as the most effective way to combat the coronavirus outbreak. SARS-CoV-2 has caused considerable mortality due to respiratory failure, highlighting the immediate need for successful therapies as well as the long-term need for antivirals to combat potential emergent mutants of coronaviruses. There are constant viral mutations are being observed due to which world is experiencing different waves of SARS-CoV-2. If our understanding of the virology and clinical presentation of COVID-19 grows, so does the pool of possible pharmacological targets. In COVID-19, the difficulties of proper analysis of current pre-clinical/clinical data as well as the creation of new evidence concerning drug repurposing will be crucial. The current manuscript aims to evaluate the repurposing of an anti-HIV drug Darunavir Ethanolate in COVID-19 treatment with in silico study and we discuss the therapeutic progress of Darunavir Etanolate, to prevent SARS-CoV-2 replication, which supports its clinical assessment for COVID-19 therapy.
登录
查看更多内容
影响因子：
5
作者：
Cameron MJ;Bermejo-Martin JF;Danesh A;Muller MP;Kelvin DJ
通讯作者：
Kelvin DJ
影响因子：
9
作者：
Channappanavar R;Perlman S
通讯作者：
Perlman S
影响因子：
5.4
作者：
Cornelissen, LAHM;Wierda, CMH;deGroot, RJ
通讯作者：
deGroot, RJ
影响因子：
5.4
作者：
Bosch, Berend Jan;Bartelink, Willem;Rottier, Peter J. M.
通讯作者：
Rottier, Peter J. M.
影响因子：
--
作者：
de Wilde AH;Snijder EJ;Kikkert M;van Hemert MJ
通讯作者：
van Hemert MJ