Modeling neuronal current MRI signal with human neuron.
Modeling neuronal current MRI signal with human neuron.
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DOI：
10.1002/mrm.22764
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发表时间：
2011-06
影响因子：
3.3
通讯作者：
Gao, Jia-Hong
中科院分区：
文献类型：
--
作者：
Luo, Qingfei;Jiang, Xia;Chen, Bin;Zhu, Yi;Gao, Jia-Hong
迄今为止，关于利用核磁共振成像（ncMRI）检测人脑神经元电流的可能性尚未达成共识。为了评估ncMRI的可检测性，用真实的神经元几何和电生理过程模拟ncMRI信号是一种有效的方法。不幸的是，以前现实的ncMRI模型是基于大鼠和猴子的神经元。神经元形态和生理的物种差异会使这些模型无法准确地模拟人类受试者的ncMRI信号。本研究的目的是通过建立一个专门针对人类大脑皮层的逼真的ncMRI模型来弥合这一差距。在这个模型中，利用解剖学重构的人类锥体神经元及其生物物理特性来模拟ncMRI信号。模拟结果表明，ncMRI信号的幅值与同步放电神经元的密度、成像体素的位置、相对于皮质表面的主磁场方向（B0）和回波时间等成像条件有关。结果表明，生理诱发的ncMRI信号太弱而无法检测到（幅度/相位变化≤-1.4×10−6/0.02°），而自发活动诱导的相位信号在有利条件下可达到可检测水平（高达0.2°）。
Up to date, no consensus has been achieved regarding the possibility of detecting neuronal currents by MRI (ncMRI) in human brain. To evaluate the detectability of ncMRI, an effective way is to simulate ncMRI signal with the realistic neuronal geometry and electrophysiological processes. Unfortunately, previous realistic ncMRI models are based on rat and monkey neurons. The species difference in neuronal morphology and physiology would prevent these models from simulating the ncMRI signal accurately in human subjects. The aim of the present study is to bridge this gap by establishing a realistic ncMRI model specifically for human cerebral cortex. In this model, the ncMRI signal was simulated using anatomically reconstructed human pyramidal neurons and their biophysical properties. The modeling results showed that the amplitude of ncMRI signal significantly depends on the density of synchronously firing neurons and imaging conditions such as position of imaging voxel, direction of main magnetic field (B0) relative to the cortical surface and echo time. The results indicated that physiologically-evoked ncMRI signal is too weak to be detected (magnitude/phase change ≤ -1.4×10−6/0.02°), but the phase signal induced by spontaneous activity may reach a detectable level (up to 0.2°) in favorable conditions.
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