Parental dietary fat intake alters offspring microbiome and immunity.
Parental dietary fat intake alters offspring microbiome and immunity.
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DOI：
10.4049/jimmunol.1301057
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发表时间：
2013-09-15
期刊：
影响因子：
--
通讯作者：
Datta SK
中科院分区：
文献类型：
--
作者：
Myles IA;Fontecilla NM;Janelsins BM;Vithayathil PJ;Segre JA;Datta SK
现代人类炎症性疾病患病率增加的潜在机制仍不清楚。卫生假说假设微生物暴露的减少在一定程度上导致了这种免疫失调。然而，膳食脂肪酸也会影响免疫力，部分是通过调节对微生物的反应。先前的报告已经描述了高脂肪饮食对肠道微生物组和炎症的直接影响，有些还显示了对后代的代谢影响。我们的研究试图扩大这些以前的观察，以确定父母的饮食对后代免疫力的影响，使用小鼠模型，以提供对人类健康的挑战方面的见解。为了检验妊娠期和哺乳期亲代膳食脂肪消耗影响后代免疫力的假设，我们比较了喂食西方饮食脂肪酸谱或标准低脂饮食的小鼠幼仔。所有幼仔均断奶至对照饮食，以专门测试早期发育脂肪暴露对免疫发育的影响。来自西方饮食饲养者的幼崽没有肥胖或糖尿病，但在感染，自身免疫和过敏致敏模型中仍然有更差的结果。他们的结肠炎症反应增强，循环细菌脂多糖（LPS）增加，全身LPS反应减弱。西方饮食的这些有害影响与后代肠道微生物组的改变有关。这些结果表明，父母的脂肪消耗可以留下影响后代免疫力的“猪油遗产”，并表明可遗传的微生物群可能有助于人类健康和疾病的现代模式。
Mechanisms underlying modern increases in prevalence of human inflammatory diseases remain unclear. The hygiene hypothesis postulates that decreased microbial exposure has, in part, driven this immune dysregulation. However, dietary fatty acids also influence immunity, partially through modulation of responses to microbes. Prior reports have described the direct effects of high fat diets on the gut microbiome and inflammation, and some have additionally shown metabolic consequences for offspring. Our study sought to expand on these previous observations to identify the effects of parental diet on offspring immunity using mouse models to provide insights into challenging aspects of human health. To test the hypothesis that parental dietary fat consumption during gestation and lactation influences offspring immunity, we compared pups of mice fed either a Western diet fatty acid profile or a standard low fat diet. All pups were weaned onto the control diet to specifically test the effects of early developmental fat exposure on immune development. Pups from Western diet breeders were not obese or diabetic, but still had worse outcomes in models of infection, autoimmunity, and allergic sensitization. They had heightened colonic inflammatory responses, with increased circulating bacterial lipopolysaccharide (LPS) and muted systemic LPS responsiveness. These deleterious impacts of the Western diet were associated with alterations of the offspring gut microbiome. These results indicate that parental fat consumption can leave a “lard legacy” impacting offspring immunity and suggest inheritable microbiota may contribute to the modern patterns of human health and disease.
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影响因子：
64.8
作者：
Devkota, Suzanne;Wang, Yunwei;Musch, Mark W.;Leone, Vanessa;Fehlner-Peach, Hannah;Nadimpalli, Anuradha;Antonopoulos, Dionysios A.;Jabri, Bana;Chang, Eugene B.
通讯作者：
Chang, Eugene B.
影响因子：
10.5
作者：
Du, Yang;Yang, Marie;Wan, Yihong
通讯作者：
Wan, Yihong
影响因子：
9.8
作者：
Damman, Christopher J.;Miller, Samuel I.;Zisman, Timothy L.
通讯作者：
Zisman, Timothy L.
DOI：
10.1038/nrgastro.2010.117
发表时间：
2010-09
期刊：
Nature reviews. Gastroenterology & hepatology
影响因子：
--
作者：
Gareau MG;Sherman PM;Walker WA
通讯作者：
Walker WA
影响因子：
3.5
作者：
Curley, James P.;Mashoodh, Rahia;Champagne, Frances A.
通讯作者：
Champagne, Frances A.