Epigenetics and the origins of paternal effects.
Epigenetics and the origins of paternal effects.
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DOI：
10.1016/j.yhbeh.2010.06.018
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发表时间：
2011-03
影响因子：
3.5
通讯作者：
Champagne, Frances A.
中科院分区：
文献类型：
--
作者：
Curley, James P.;Mashoodh, Rahia;Champagne, Frances A.
虽然父母可以通过多种途径影响后代，但最近对环境诱导的表观遗传变异的研究突出了非基因组途径的作用。除了可以通过母婴相互作用实现的DNA甲基化的经验依赖性修饰外，人们对表观遗传机制的兴趣也越来越大，通过表观遗传机制可以实现父亲对后代发育的影响。流行病学和实验室研究表明，父亲的营养和毒理学暴露以及父亲的年龄和表型变异可导致后代的变异，在某些情况下，还可导致孙辈发育的变异。这些发现表明，一个潜在的表观遗传生殖系遗传的父亲的影响。然而，它可能是重要的是要考虑到母亲和父亲的影响之间的相互作用，以及经验依赖和生殖系传播之间的实验分离时，探索生殖系内的表观遗传变异的作用，作为这些影响的调解人。在这篇综述中，我们将探讨这些问题，特别是注重父亲引起的母亲投资的潜在作用，突出说明父亲的经验的跨代影响的文献，并讨论支持表观遗传机制的作用，在保持父亲的影响内和跨代的证据。
Though there are multiple routes through which parents can influence their offspring, recent studies of environmentally induced epigenetic variation have highlighted the role of non-genomic pathways. In addition to the experience-dependent modification of DNA methylation that can be achieved via mother-infant interactions, there has been increasing interest in the epigenetic mechanisms through which paternal influences on offspring development can be achieved. Epidemiological and laboratory studies suggest that paternal nutritional and toxicological exposures as well as paternal age and phenotypic variation can lead to variations in offspring and, in some cases, grand-offspring development. These findings suggest a potential epigenetic germline inheritance of paternal effects. However, it may be important to consider the interplay between maternal and paternal influences as well as the experimental dissociation between experience-dependent and germline transmission when exploring the role of epigenetic variation within the germline as a mediator of these effects. In this review, we will explore these issues, with a particular focus on the potential role of paternally-induced maternal investment, highlight the literature illustrating the transgenerational impact of paternal experiences, and discuss the evidence supporting the role of epigenetic mechanisms in maintaining paternal effects both within and across generations.
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影响因子：
10.6
作者：
Alter MD;Gilani AI;Champagne FA;Curley JP;Turner JB;Hen R
通讯作者：
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影响因子：
2.9
作者：
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2.5
作者：
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通讯作者：
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