Cutaneous squamous cell carcinoma and human papillomavirus: is there an association?
Cutaneous squamous cell carcinoma and human papillomavirus: is there an association?
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DOI：
10.1111/j.1524-4725.2012.02558.x
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发表时间：
2013-01
期刊：
影响因子：
--
通讯作者：
Arron ST
中科院分区：
文献类型：
--
作者：
Aldabagh B;Angeles JG;Cardones AR;Arron ST
人乳头状瘤病毒（HPV）在宫颈癌、肛门生殖器癌和某些口咽癌的诱导和维持中的作用是公认的。然而，其在皮肤鳞状细胞癌（SCC）中的作用仍有待阐明。HPV被认为是SCC发展过程中可能的共致癌物。回顾文献，评估免疫功能正常和免疫功能低下人群中HPV和皮肤鳞状细胞癌的相关性和可能的原因。我们回顾了HPV采样和检测方法，流行病学研究检查HPV携带免疫功能正常和免疫抑制的个人，和证据断言HPV和皮肤SCC之间的关联。虽然大量证据表明HPV和皮肤SCC之间存在联系，但许多研究表明并非如此。最近的研究集中在病毒活动，除了DNA的存在。HPV可能在皮肤SCC的诱导而非维持中起作用。
The role of human papillomavirus (HPV) in the induction and maintenance of cervical, anogenital, and some oropharyngeal carcinomas is well recognized. However, its role in cutaneous squamous cell carcinoma (SCC) remains to be elucidated. HPV is thought to act as a possible co-carcinogen in the development of SCC. To review the literature assessing the correlation and possible causation of HPV and cutaneous SCC in the immunocompetent and immunocompromised populations. We reviewed HPV sampling and detection methods, epidemiologic studies examining HPV carriage in immunocompetent and immunosuppressed individuals, and evidence asserting an association between HPV and cutaneous SCC. Although an abundant body of evidence points toward a link between HPV and cutaneous SCC, many studies indicate otherwise. Recent studies have focused on viral activity in addition to DNA presence. The possibility exists that HPV may play a role in the induction but not maintenance of cutaneous SCC.
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