Long-Term Association Between Maternal Preconception Hemoglobin Concentration, Anemia, and Child Health and Development in Vietnam.
Long-Term Association Between Maternal Preconception Hemoglobin Concentration, Anemia, and Child Health and Development in Vietnam.
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DOI：
10.1016/j.tjnut.2023.03.015
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发表时间：
2023-05
期刊：
影响因子：
--
通讯作者：
Ramakrishnan U
中科院分区：
文献类型：
--
作者：
Young MF;Nguyen P;Tran LM;Khuong LQ;Martorell R;Ramakrishnan U
孕前母亲血红蛋白 (Hb) 浓度与儿童健康和发育之间的长期关联尚不清楚。我们研究了母亲孕前血红蛋白浓度与贫血之间的关系：1）出生结局（体重、身长、早产、胎龄、小于胎龄）； 2) 儿童 3 个月、6 个月、12 个月和 24 个月时的 Hb； 3) 12 个月和 24 个月时的运动和智力发育（婴儿发育贝利量表）以及 6-7 岁时的认知功能（韦克斯勒儿童智力量表）。我们使用了在越南进行的随机对照试验 (PRECONCEPT) 的数据。招募了超过 5000 名打算怀孕的女性，并对后代从出生 (n = 1599) 到 6-7 年 (n = 1318) 进行前瞻性随访。使用多变量线性和逻辑回归来评估孕前 Hb 或贫血 (Hb < 12g/dL) 与儿童健康和发育结果之间的关联，并通过补充剂组（相互作用测试）和孕产妇、儿童和家庭层面的混杂因素进行调整。在孕前登记时，20% 的女性患有贫血。母亲孕前 Hb 与儿童 3 个月（0.06；95% CI：0.01，0.12）、6 个月（0.08；95% CI：0.03，0.13）、12 个月（0.10；95% CI：0.04，0.15）和 24 个月（0.07；95% CI）时的 Hb 呈正相关置信区间：0.02、0.12）。同样，母亲孕前 Hb 与 6 个月（0.89；95% CI：0.81，0.98）、12 个月（0.81；95% CI：0.74，0.89）和 24 个月（0.87；95% CI：0.79，0.95）儿童贫血风险降低相关。母亲孕前贫血与 24 个月时的认知（-1.64；95% CI：-3.09，-0.19）和语言发展（-1.61；95% CI：-3.20，-0.03）呈负相关。孕前 Hb 与出生结果或 6-7 岁时的认知结果无关。母亲孕前 Hb 与儿童出生后 1000 天内的 Hb 相关。然而，在越南队列中，孕前 Hb 并不是出生结果或 6-7 岁时认知结果的显着预测因子。孕前研究（NCT：01665378）。
The long-term association between preconception maternal hemoglobin (Hb) concentrations and child health and development is unclear. We examined associations between maternal preconception Hb concentrations and anemia with 1) birth outcomes (weight, length, preterm, gestational age, small for gestational age); 2) child Hb at 3 mo, 6 mo, 12 mo, and 24 mo; and 3) motor and mental development at 12 mo and 24 mo (Bayley scales for infant development) and cognitive functioning at 6–7 y (Wechsler Intelligence Scale for Children). We used data from a randomized controlled trial (PRECONCEPT) conducted in Vietnam. Over 5000 women who were intending to conceive were recruited, and offspring were prospectively followed from birth (n = 1599) through 6–7 y (n = 1318). Multivariable linear and logistic regressions were used to assess the association between preconception Hb or anemia (Hb < 12g/dL) on child health and development outcomes, adjusted by supplementation group (tested for interactions) and confounding at maternal, child, and household levels. At preconception enrollment, 20% of the women were anemic. Maternal preconception Hb was positively associated with child Hb at 3 mo (0.06; 95% CI: 0.01, 0.12), 6 mo (0.08; 95% CI: 0.03, 0.13), 12 mo (0.10; 95% CI: 0.04, 0.15), and 24 mo (0.07; 95% CI: 0.02, 0.12). Likewise, maternal preconception Hb was associated with reduced risk of child anemia at 6 mo (0.89; 95% CI: 0.81, 0.98), 12 mo (0.81; 95% CI: 0.74, 0.89), and 24 mo (0.87; 95% CI: 0.79, 0.95). Maternal preconception anemia was negatively associated with cognition (−1.64; 95% CI: −3.09, −0.19) and language development (−1.61; 95% CI: −3.20, −0.03) at 24 mo. Preconception Hb was not associated with birth outcomes or cognitive outcomes at 6–7 y. Maternal preconception Hb was associated with child Hb across the first 1000 d of life. However, preconception Hb was not a significant predictor of birth outcomes or cognitive outcomes at 6–7 y in this cohort from Vietnam. PRECONCEPT study (NCT: 01665378).
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DOI：
10.1016/s0140-6736(16)31389-7
发表时间：
2017-01-07
期刊：
Lancet (London, England)
影响因子：
--
作者：
Black MM;Walker SP;Fernald LCH;Andersen CT;DiGirolamo AM;Lu C;McCoy DC;Fink G;Shawar YR;Shiffman J;Devercelli AE;Wodon QT;Vargas-Barón E;Grantham-McGregor S;Lancet Early Childhood Development Series Steering Committee
通讯作者：
Lancet Early Childhood Development Series Steering Committee
影响因子：
5.6
作者：
Leonard, Helen;De Klerk, Nick;Bower, Carol
通讯作者：
Bower, Carol
影响因子：
3.4
作者：
Dean SV;Lassi ZS;Imam AM;Bhutta ZA
通讯作者：
Bhutta ZA
影响因子：
168.9
作者：
Black, Robert E.;Victora, Cesar G.;Uauy, Ricardo
通讯作者：
Uauy, Ricardo
影响因子：
1.4
作者：
Hirata, Michio;Kusakawa, Isao;Yoda, Hitoshi
通讯作者：
Yoda, Hitoshi