Laminar responses in the auditory cortex using a multielectrode array substrate for simultaneous stimulation and recording
Laminar responses in the auditory cortex using a multielectrode array substrate for simultaneous stimulation and recording
复制标题
使用多电极阵列基板同时刺激和记录听觉皮层的层状反应
DOI:
10.1002/tee.22810
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发表时间:
2018
影响因子:
1
通讯作者:
Tateno Takashi
中科院分区:
文献类型:
--
作者:
Takahashi Sota;Muramatsu Shuto;Nishikawa Jun;Satoh Kazuo;Murakami Shuichi;Tateno Takashi
Here, we report the design, fabrication, and characterization of a multielectrode array (MEA) substrate for the use of simultaneous stimulation and recordingin vivo. The fabricated substrate has two sharp shanks in which we arranged multiple electrode arrays with surface areas of 50 × 50 µm2in one shank for stimulation (interelectrode interval, 150 µm) and 15 × 15 µm2in the other for recording (interelectrode interval, 100 µm). Our impedance measurements show that the electrode values are in good agreement with specified values for silicon‐based commercially available devices or slightly smaller‐sized electrode devices. After electrode characterization, the MEAs were evaluated for simultaneous stimulation and acute neural recording in the mouse auditory cortexin vivo. Using MEA substrates, we recorded spatiotemporal local field potential profiles driven by short local electrical stimulation, particularly to layer 4 of the mouse auditory cortex. Our results demonstrate successful simultaneous stimulation and recordings using the devicesin vivo. Indeed, the device may contribute to understanding similarities and differences in local network activity driven by sound stimulation and electric microstimulation in near future work. © 2018 Institute of Electrical Engineers of Japan. Published by John Wiley & Sons, Inc.
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影响因子:
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影响因子:
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DOI:
10.1201/b16408-3
发表时间:
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期刊:
--
影响因子:
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