Association of serum carotenoid levels with urinary albumin excretion in a general Japanese population: the Yakumo study.
Association of serum carotenoid levels with urinary albumin excretion in a general Japanese population: the Yakumo study.
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DOI：
10.2188/jea.je20130058
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发表时间：
2013
影响因子：
4.7
通讯作者：
Inoue T
中科院分区：
文献类型：
--
作者：
Suzuki K;Honjo H;Ichino N;Osakabe K;Sugimoto K;Yamada H;Kusuhara Y;Watarai R;Hamajima T;Hamajima N;Inoue T
蛋白尿不仅是肾病进展的危险因素，也是心血管疾病的危险因素。氧化应激可能在蛋白尿和心血管疾病之间的正相关中起作用。这项横断面研究调查了501名日本成年人(男性198名，平均年龄±SD：66.4±10.0岁；女性303名，平均年龄±SD：65.4±9.8岁)血清类胡萝卜素水平与蛋白尿的关系。用高效液相色谱法测定血清类胡萝卜素水平。Logistic回归分析用于估计在调整了年龄、体重指数、吸烟习惯、饮酒习惯、高血压、糖尿病和血脂异常后，蛋白尿的优势比(OR)为95%。男性蛋白尿患病率为15.4%，女性为18.1%。在有蛋白尿的女性中，血清角黄素、番茄红素、β-胡萝卜素、总胡萝卜素和维生素A原的几何平均水平显著低于正常蛋白尿女性。在血清β-胡萝卜素(OR，0.45；95%CI，0.20~0.98)和维生素A原(OR，0.45；95%CI，0.20~0.97)水平最高的女性中，蛋白尿的调整OR值显著低于最低三分位数的女性。在男性中，血清类胡萝卜素与蛋白尿之间没有关联。在日本女性中，血清维生素A原水平的升高，特别是血清β-胡萝卜素水平的升高，与较低的蛋白尿风险独立相关。
Albuminuria is a risk factor for not only nephropathy progression but also cardiovascular disease. Oxidative stress may have a role in the positive association between albuminuria and cardiovascular disease. This cross-sectional study investigated the associations of serum levels of carotenoids, which are dietary antioxidants, with albuminuria among 501 Japanese adults (198 men, mean age ± SD: 66.4 ± 10.0 years; 303 women, mean age ± SD: 65.4 ± 9.8 years) who attended a health examination. Serum levels of carotenoids were determined by high-performance liquid chromatography. Logistic regression analysis was used to estimate odds ratios (ORs) with 95% CIs for albuminuria after adjustment for age, body mass index, smoking habits, drinking habits, hypertension, diabetes mellitus, and dyslipidemia. Prevalence of albuminuria was 15.4% among men and 18.1% among women. Among women with albuminuria, geometric mean serum levels of canthaxanthin, lycopene, β-carotene, total carotenes, and provitamin A were significantly lower than those of normoalbuminuric women. Adjusted ORs for albuminuria among women in the highest tertiles of serum β-carotene (OR, 0.45; 95% CI, 0.20–0.98) and provitamin A (OR, 0.45; 95% CI, 0.20–0.97) were significantly lower as compared with those for women in the lowest tertile. There were no associations between serum carotenoids and albuminuria in men. An increased level of serum provitamin A, especially serum β-carotene, was independently associated with lower risk of albuminuria among Japanese women.
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影响因子：
1.8
作者：
Nerpin E;Helmersson-Karlqvist J;Risérus U;Sundström J;Larsson A;Jobs E;Basu S;Ingelsson E;Arnlöv J
通讯作者：
Arnlöv J
影响因子：
4.7
作者：
Ito Y;Kurata M;Suzuki K;Hamajima N;Hishida H;Aoki K
通讯作者：
Aoki K
影响因子：
11.1
作者：
Giner, V;Tormos, C;Redón, J
通讯作者：
Redón, J
影响因子：
120.7
作者：
Gerstein, HC;Mann, JFE;Yusuf, S
通讯作者：
Yusuf, S
DOI：
10.1007/bf00210955
发表时间：
1993-01-01
期刊：
CLINICAL INVESTIGATOR
影响因子：
--
作者：
GEY, KF;STAHELIN, HB;EICHHOLZER, M
通讯作者：
EICHHOLZER, M