The BRENDA Tissue Ontology (BTO): the first all-integrating ontology of all organisms for enzyme sources.
The BRENDA Tissue Ontology (BTO): the first all-integrating ontology of all organisms for enzyme sources.
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DOI：
10.1093/nar/gkq968
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发表时间：
2011-01
影响因子：
14.9
通讯作者：
Schomburg D
中科院分区：
文献类型：
--
作者：
Gremse M;Chang A;Schomburg I;Grote A;Scheer M;Ebeling C;Schomburg D
BTO，BRENDA 组织本体论 (http://www.BTO.brenda-enzymes.org) 代表了组织术语的全面结构化百科全书。该项目始于 2003 年，旨在在 BRENDA 酶数据库的酶数据收集与源组织和细胞类型的结构化网络之间建立连接。目前，BTO 包含 4600 多种不同的解剖结构、组织、细胞类型和细胞系，按照与基因本体联盟的规则和格式相对应的通用类别进行分类，并组织为有向无环图 (DAG)。大多数术语都附有对其派生或定义的注释。本体的内容每年不断地更新约 1000 个新术语。术语之间实现了四种不同类型的关系。具有多种搜索和导航功能的多功能网络界面可以方便地在线访问 BTO 和从组织中分离的酶。 BTO 术语的重要应用领域是组织中酶的检测以及为该领域的文本挖掘方法提供坚实的基础。它被实验室科学家、基因组和生化数据库管理员以及生物信息学家广泛使用。 BTO 可在 http://www.obofoundry.org 上免费获取。
BTO, the BRENDA Tissue Ontology (http://www.BTO.brenda-enzymes.org) represents a comprehensive structured encyclopedia of tissue terms. The project started in 2003 to create a connection between the enzyme data collection of the BRENDA enzyme database and a structured network of source tissues and cell types. Currently, BTO contains more than 4600 different anatomical structures, tissues, cell types and cell lines, classified under generic categories corresponding to the rules and formats of the Gene Ontology Consortium and organized as a directed acyclic graph (DAG). Most of the terms are endowed with comments on their derivation or definitions. The content of the ontology is constantly curated with ∼1000 new terms each year. Four different types of relationships between the terms are implemented. A versatile web interface with several search and navigation functionalities allows convenient online access to the BTO and to the enzymes isolated from the tissues. Important areas of applications of the BTO terms are the detection of enzymes in tissues and the provision of a solid basis for text-mining approaches in this field. It is widely used by lab scientists, curators of genomic and biochemical databases and bioinformaticians. The BTO is freely available at http://www.obofoundry.org.
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影响因子：
46.9
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