Current Applications and Future Development of Magnetic Resonance Fingerprinting in Diagnosis, Characterization, and Response Monitoring in Cancer.
Current Applications and Future Development of Magnetic Resonance Fingerprinting in Diagnosis, Characterization, and Response Monitoring in Cancer.
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DOI：
10.3390/cancers13194742
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发表时间：
2021-09-22
期刊：
影响因子：
5.2
通讯作者：
Adeleke S
中科院分区：
文献类型：
--
作者：
Ding H;Velasco C;Ye H;Lindner T;Grech-Sollars M;O'Callaghan J;Hiley C;Chouhan MD;Niendorf T;Koh DM;Prieto C;Adeleke S
磁共振指纹识别 (MRF) 是一种用于采集共同配准的多参数磁共振图谱并提高扫描效率的框架。许多研究探索了 MRF 在癌症治疗中的应用。对该领域当前发展的回顾尚未撰写，但需要让临床医生和研究人员了解最新情况。本综述总结了最近使用 MRF 检测和表征肿瘤的研究，重点关注脑肿瘤、前列腺癌和腹部/盆腔癌。还提到了 MRF 在放射治疗计划方面的进展。 MRF 的原理和局限性已得到简化，以提高具有最低放射学背景的临床医生的可及性。探讨了 MRF 未来的肿瘤学应用，包括整合 MRF 和深度学习，以及使用 MRF 评估疾病异质性。我们建议在 MRF 能够提供评估肿瘤生物标志物或被临床医生接受的可靠方法之前需要进行进一步的研究。磁共振成像 (MRI) 使常见临床环境中的非侵入性癌症诊断、监测和管理成为可能。然而，MRI 定量分析的不足继续限制了其全部潜力，并且常常影响临床医生的判断。最近引入了磁共振指纹识别（MRF），可以在合理的时间范围内同时获取多个定量参数。最初的回顾性研究已经证明了使用 MRF 来表征各种癌症的可行性。仍需要对更大的队列进行进一步的试验，以探索 MRF 获取的数据的重复性和再现性。目前，处理时间过长或缺乏运动鲁棒性等技术难题限制了 MRF 在临床肿瘤学中的进一步实施。本综述总结了 MRF 在癌症管理中使用的最新发现和技术发展，并提出了 MRF 在表征肿瘤异质性和反应评估方面可能的未来影响。
Magnetic resonance fingerprinting (MRF) is a framework for acquiring co-registered multiparametric magnetic resonance mapping with increased scan efficiency. Many studies have explored the use of MRF for cancer management. A review on the current developments in this area has not yet been written but is needed to keep both clinicians and researchers updated. This review summarises recent studies detecting and characterising tumours using MRF, with a focus on brain tumours, prostate cancers, and abdominal/pelvic cancers. Advances in MRF for radiotherapy planning are also mentioned. The principles and limitations of MRF have been simplified to increase accessibility to clinicians with minimal radiological backgrounds. Future oncological applications of MRF are explored, including integrating MRF and deep learning, as well as the use of MRF in assessing disease heterogeneity. We propose further research that needs to take place before MRF can provide a credible means for assessing tumour biomarkers or be accepted by clinicians. Magnetic resonance imaging (MRI) has enabled non-invasive cancer diagnosis, monitoring, and management in common clinical settings. However, inadequate quantitative analyses in MRI continue to limit its full potential and these often have an impact on clinicians’ judgments. Magnetic resonance fingerprinting (MRF) has recently been introduced to acquire multiple quantitative parameters simultaneously in a reasonable timeframe. Initial retrospective studies have demonstrated the feasibility of using MRF for various cancer characterizations. Further trials with larger cohorts are still needed to explore the repeatability and reproducibility of the data acquired by MRF. At the moment, technical difficulties such as undesirable processing time or lack of motion robustness are limiting further implementations of MRF in clinical oncology. This review summarises the latest findings and technology developments for the use of MRF in cancer management and suggests possible future implications of MRF in characterizing tumour heterogeneity and response assessment.
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影响因子：
3.3
作者：
Anderson CE;Wang CY;Gu Y;Darrah R;Griswold MA;Yu X;Flask CA
通讯作者：
Flask CA
影响因子：
3.3
作者：
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Madore B
影响因子：
4.6
作者：
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通讯作者：
Makowski, Marcus R.
影响因子：
3.3
作者：
Cohen O;Zhu B;Rosen MS
通讯作者：
Rosen MS
影响因子：
2.9
作者：
Cruz, Gastao;Jaubert, Olivier;Prieto, Claudia
通讯作者：
Prieto, Claudia