Dietary advanced glycation end products and cancer risk in Japan: From the Takayama study.
Dietary advanced glycation end products and cancer risk in Japan: From the Takayama study.
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DOI：
10.1111/cas.15455
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发表时间：
2022-08
期刊：
影响因子：
5.7
通讯作者：
Nagata, Chisato
中科院分区：
文献类型：
--
作者：
Wada, Keiko;Nakashima, Yuma;Yamakawa, Michiyo;Hori, Akihiro;Seishima, Mitsuru;Tanabashi, Shinobu;Matsushita, Shogen;Tokimitsu, Naoki;Nagata, Chisato
很少有大型流行病学研究评估了膳食晚期糖基化终末产物 (AGE) 与癌症风险之间的关联。我们在日本进行的一项基于人群的前瞻性研究中评估了膳食 AGE 摄入量与总癌症和特定部位癌症发病率之间的关系。 1992 年，参与者有 14,173 名男性和 16,549 名女性，年龄在 35 岁或以上。通过经过验证的食物频率调查问卷评估膳食摄入量。使用超高效液相色谱-串联质谱法确定的食品中 CML 含量数据库来估算 AGE N ε-羧甲基赖氨酸 (CML) 的摄入量。癌症发病率是通过区域人口癌症登记处确认的。在平均 13.3 年的随访期间，1954 名男性和 1477 名女性罹患癌症。我们没有观察到男性或女性 CML 摄入量与患总癌症的风险之间存在显着关联。在男性中，与 CML 摄入量最低四分位相比，第二、第三和最高四分位的肝癌风险比分别为 1.69 (95% CI: 0.92–3.10)、1.48 (95% CI: 0.77–2.84) 和 2.10 (95% CI: 1.10–3.98；趋势 p = 0.04)。相反，与最低四分位数相比，CML 摄入量的第二个和最高四分位数的男性患胃癌的相对风险降低，风险比分别为 0.73 和 0.67（趋势 p = 0.08）。我们关于食用 AGEs 对肝癌风险的潜在危害的发现很有趣，值得进一步研究。日本男性摄入大量晚期糖基化终产物 Nε-羧甲基-赖氨酸与肝癌风险增加相关。我们的研究结果表明，食用晚期糖基化终产物对肝癌风险具有潜在危害。
Few large epidemiological studies have evaluated the association between dietary advanced glycation end products (AGEs) and cancer risk. We evaluated the relationship between dietary AGE intake and the incidence of total cancer and site‐specific cancers in a population‐based prospective study in Japan. Participants were 14,173 men and 16,549 women who were 35 years of age or older in 1992. Dietary intake was assessed via a validated food frequency questionnaire. Intake of the AGE N ε‐carboxymethyl‐lysine (CML) was estimated using databases of CML content in foods determined using ultraperformance liquid chromatography–tandem mass spectrometry. Cancer incidence was confirmed through regional population‐based cancer registries. During a mean follow‐up period of 13.3 years, 1954 men and 1477 women developed cancer. We did not observe a significant association between CML intake and the risk of total cancer in men or women. In men, compared with the lowest quartile of CML intake, the hazard ratios of liver cancer for the second, third, and highest quartiles were 1.69 (95% CI: 0.92–3.10), 1.48 (95% CI: 0.77–2.84), and 2.10 (95% CI: 1.10–3.98; trend p = 0.04). Conversely, a decreased relative risk of male stomach cancer was observed for the second and highest quartiles of CML intake versus the lowest quartile, with hazard ratios of 0.73 and 0.67, respectively (trend p = 0.08). Our finding on the potential harmfulness of consuming AGEs on liver cancer risk is intriguing and warrants further study. A high intake of advanced glycation end products Nε‐carboxymethyl‐lysine was associated with an increased risk of liver cancer in Japanese men. Our finding suggests the potential harmfulness of consuming advanced glycation end products on liver cancer risk.
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影响因子：
3.7
作者：
Patel R;Baker SS;Liu W;Desai S;Alkhouri R;Kozielski R;Mastrandrea L;Sarfraz A;Cai W;Vlassara H;Patel MS;Baker RD;Zhu L
通讯作者：
Zhu L
影响因子：
5.6
作者：
Kishi S;Nishiguchi Y;Honoki K;Mori S;Fujiwara-Tani R;Sasaki T;Fujii K;Kawahara I;Goto K;Nakashima C;Kido A;Tanaka Y;Luo Y;Kuniyasu H
通讯作者：
Kuniyasu H
影响因子：
6.2
作者：
Peterson, Lindsay L.;Park, Seho;Turner, David P.
通讯作者：
Turner, David P.
影响因子：
2.4
作者：
Hull, George L. J.;Woodside, Jayne V.;Cuskelly, Geraldine J.
通讯作者：
Cuskelly, Geraldine J.
影响因子：
5.9
作者：
Aglago EK;Mayén AL;Knaze V;Freisling H;Fedirko V;Hughes DJ;Jiao L;Eriksen AK;Tjønneland A;Boutron-Ruault MC;Rothwell JA;Severi G;Kaaks R;Katzke V;Schulze MB;Birukov A;Palli D;Sieri S;Santucci de Magistris M;Tumino R;Ricceri F;Bueno-de-Mesquita B;Derksen JWG;Skeie G;Gram IT;Sandanger T;Quirós JR;Luján-Barroso L;Sánchez MJ;Amiano P;Chirlaque MD;Gurrea AB;Johansson I;Manjer J;Perez-Cornago A;Weiderpass E;Gunter MJ;Heath AK;Schalkwijk CG;Jenab M
通讯作者：
Jenab M