Challenges for the Newborn Immune Response to Respiratory Virus Infection and Vaccination.
Challenges for the Newborn Immune Response to Respiratory Virus Infection and Vaccination.
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DOI：
10.3390/vaccines8040558
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发表时间：
2020-09-24
期刊：
影响因子：
7.8
通讯作者：
Alexander-Miller MA
中科院分区：
文献类型：
--
作者：
Crofts KF;Alexander-Miller MA
生命的最初几个月反映了新生儿极具挑战性的时期，因为幼稚的免疫系统受到大量病原体、共生体和其他外来实体的轰炸。在许多情况下，幼儿的免疫反应受到抑制或改变，导致感染后易感性增加和疾病发生。这是整个免疫系统中多种细胞类型反应的质和量变化的结果。在这里，我们回顾了与新生儿对呼吸道病毒病原体的反应相关的挑战，以及疫苗介导的保护的障碍和进展。
The initial months of life reflect an extremely challenging time for newborns as a naïve immune system is bombarded with a large array of pathogens, commensals, and other foreign entities. In many instances, the immune response of young infants is dampened or altered, resulting in increased susceptibility and disease following infection. This is the result of both qualitative and quantitative changes in the response of multiple cell types across the immune system. Here we provide a review of the challenges associated with the newborn response to respiratory viral pathogens as well as the hurdles and advances for vaccine-mediated protection.
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DOI：
10.1093/cid/ciaa648
发表时间：
2021-12-06
期刊：
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
影响因子：
--
作者：
Buchwald AG;Graham BS;Traore A;Haidara FC;Chen M;Morabito K;Lin BC;Sow SO;Levine MM;Pasetti MF;Tapia MD
通讯作者：
Tapia MD
影响因子：
17.1
作者：
Andrews SF;Huang Y;Kaur K;Popova LI;Ho IY;Pauli NT;Henry Dunand CJ;Taylor WM;Lim S;Huang M;Qu X;Lee JH;Salgado-Ferrer M;Krammer F;Palese P;Wrammert J;Ahmed R;Wilson PC
通讯作者：
Wilson PC
影响因子：
4.4
作者：
Basha S;Surendran N;Pichichero M
通讯作者：
Pichichero M
DOI：
10.1093/cid/ciu354
发表时间：
2014-08-15
期刊：
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
影响因子：
--
作者：
Aaby P;Martins CL;Garly ML;Andersen A;Fisker AB;Claesson MH;Ravn H;Rodrigues A;Whittle HC;Benn CS
通讯作者：
Benn CS
影响因子：
2.2
作者：
Altman, Meghan O.;Angeletti, Davide;Yewdell, Jonathan W.
通讯作者：
Yewdell, Jonathan W.