A functional polymorphism in the pre-miR-146a gene is associated with risk and prognosis in adult glioma.
A functional polymorphism in the pre-miR-146a gene is associated with risk and prognosis in adult glioma.
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DOI：
10.1007/s11060-011-0634-1
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发表时间：
2011-12
影响因子：
3.9
通讯作者：
Egan, Kathleen M.
中科院分区：
文献类型：
--
作者：
Permuth-Wey, Jennifer;Thompson, Reid C.;Nabors, L. Burton;Olson, Jeffrey J.;Browning, James E.;Madden, Melissa H.;Chen, Y. Ann;Egan, Kathleen M.
微小RNA（microRNAs，miRNAs）是一类非编码RNA，在肿瘤抑制基因和癌基因的转录后调控中发挥重要作用。miRNAs的单核苷酸多态性（single nucleotide polymorphism，SNPs）可能通过改变miRNAs及其靶基因的表达而促进肿瘤的发生。miR-146 a前体序列中的G>C多态性（rs 2910164）导致与许多恶性肿瘤风险相关的功能变化。这种SNP在神经胶质瘤发病机制中的作用尚未得到研究。我们在一项多中心病例对照研究中调查了rs 2910164基因型是否影响胶质瘤的风险和预后，该研究包括593例高加索胶质瘤病例和614例社区对照。采用非条件logistic回归分析，根据病例状态估计rs 2910164基因型的比值比（OR）和95%置信区间（CI）。考克斯比例风险回归模型被用来估计风险比（HR）和95% CI根据基因型之间的胶质母细胞瘤，最致命的胶质瘤亚型。在rs 2910164次要等位基因（C）携带者中观察到胶质瘤风险增加（每个等位基因OR（95%CI）= 1.22（1.01-1.46，ptrend = 0.039））。在携带至少一个C等位基因拷贝的老年受试者中，这种关联更强（OR（95%CI）= 1.38（1.04-1.83，P = 0.026）。次要等位基因携带者的死亡率增加（HR（95% CI）= 1.33（1.03-1.72，P = 0.029）），相关性主要限于女性（HR（95% CI）= 2.02（1.28-3.17，P = 0.002））。我们提供了新的数据表明rs 2910164基因型可能有助于胶质瘤的易感性和结果。未来的研究有必要复制这些发现，并描述这些关联的机制。
MicroRNAs (miRNAs) are non-coding RNAs that function as post-transcriptional regulators of tumor suppressors and oncogenes. Single nucleotide polymorphisms (SNPs) in miRNAs may contribute to carcinogenesis by altering expression of miRNAs and their targets. A G>C polymorphism (rs2910164) in the miR-146a precursor sequence leads to a functional change associated with the risk for numerous malignancies. A role for this SNP in glioma pathogenesis has not yet been examined. We investigated whether rs2910164 genotypes influence glioma risk and prognosis in a multi-center case–control study comprised of 593 Caucasian glioma cases and 614 community-based controls. Unconditional logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI) for rs2910164 genotypes according to case status. Cox proportional hazards regression modeling was used to estimate hazards ratios (HR) and 95% CIs according to genotype among glioblastomas, the most lethal glioma subtype. An increased glioma risk was observed among rs2910164 minor allele (C) carriers (per allele OR (95% CI) = 1.22 (1.01–1.46, ptrend = 0.039)). The association was stronger among older subjects carrying at least one copy of the C allele (OR (95% CI) = 1.38 (1.04–1.83, P = 0.026). Mortality was increased among minor allele carriers (HR (95% CI) = 1.33 (1.03–1.72, P = 0.029)), with the association largely restricted to females (HR (95% CI) = 2.02 (1.28–3.17, P = 0.002)). We provide novel data suggesting rs2910164 genotype may contribute to glioma susceptibility and outcome. Future studies are warranted to replicate these findings and characterize mechanisms underlying these associations.
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影响因子：
30.8
作者：
Shete S;Hosking FJ;Robertson LB;Dobbins SE;Sanson M;Malmer B;Simon M;Marie Y;Boisselier B;Delattre JY;Hoang-Xuan K;El Hallani S;Idbaih A;Zelenika D;Andersson U;Henriksson R;Bergenheim AT;Feychting M;Lönn S;Ahlbom A;Schramm J;Linnebank M;Hemminki K;Kumar R;Hepworth SJ;Price A;Armstrong G;Liu Y;Gu X;Yu R;Lau C;Schoemaker M;Muir K;Swerdlow A;Lathrop M;Bondy M;Houlston RS
通讯作者：
Houlston RS
影响因子：
3.8
作者：
Scheurer, Michael E.;Etzel, Carol J.;Bondy, Melissa L.
通讯作者：
Bondy, Melissa L.
影响因子：
9.1
作者：
Okubo, Masaaki;Tahara, Tomomitsu;Arisawa, Tomiyasu
通讯作者：
Arisawa, Tomiyasu
影响因子：
3.6
作者：
do Carmo, Analia;Patricio, Ines;Lopes, Maria C.
通讯作者：
Lopes, Maria C.
microRNA196a基因组区域的多态性与中国人群患神经胶质瘤的风险降低相关
DOI：
10.1007/s00432-010-0844-5
发表时间：
2010-12-01
影响因子：
3.6
作者：
Dou, Tonghai;Wu, Qihan;Lu, Daru
通讯作者：
Lu, Daru