Reduced thalamic volumes in major depressive disorder.
Reduced thalamic volumes in major depressive disorder.
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DOI：
10.1016/j.pscychresns.2013.05.004
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发表时间：
2013-09-30
影响因子：
11.3
通讯作者：
Drevets WC
中科院分区：
文献类型：
--
作者：
Nugent AC;Davis RM;Zarate CA Jr;Drevets WC
边缘-皮质-纹状体-苍白球-丘脑（LCSPT）回路的功能改变与重度抑郁症（MDD）的病理生理学有关。本研究评价了抑郁MDD受试者（N=142）、缓解期MDD受试者（N=72）和健康对照者（N=169）之间皮质下体积的差异。参与者接受磁共振成像（MRI）扫描，并使用FIRST（FMRIB的集成配准和分割工具，英国牛津大学）提取皮质下体积。抑郁症患者双侧丘脑和海马的体积明显小于对照组，在控制颅内总体积后，双侧丘脑的差异仍然显著。在健康对照组和与缓解的MDD受试者相匹配的抑郁MDD受试者的较小子集中，观察到双侧丘脑以及右侧尾状核、海马和苍白球的体积在各组之间存在显著差异;这些主要是由抑郁的MDD受试者与缓解的和健康的受试者之间的差异引起的，尽管在控制了颅内总容积（TIV）后，这些变化均不显著。丘脑和海马的体积减少可能导致皮质下-皮质网络内的功能障碍，这与MDD中这些区域的代谢和血流动力学异常的既往证据一致。
Altered function in the limbic-cortical-striatial-pallidal-thalamic (LCSPT) circuit has been implicated in the pathophysiology of major depressive disorder (MDD). This study evaluated volumetric differences in subcortical volumes between depressed subjects with MDD (N=142), subjects with MDD in remission (N=72), and healthy controls (N=169). Participants underwent magnetic resonance imaging (MRI) scanning, and subcortical volumes were extracted using FIRST (FMRIB’s Integrated Registration and Segmentation Tool, University of Oxford, UK). The depressed MDD subjects exhibited significantly smaller volumes in the bilateral thalamus and hippocampus compared to control subjects, and the differences in the bilateral thalamus remained significant after controlling for total intracranial volume. In a smaller subset of healthy controls and depressed MDD subjects matched to the remitted MDD subjects, significant differences in volume were observed across groups in the bilateral thalamus, as well as the right lateralized caudate, hippocampus, and pallidum; these were primarily accounted for by differences between the depressed MDD subjects versus both the remitted and healthy subjects, though none of these changes remained significant after controlling for total intracranial volume (TIV). Volumetric reductions in the thalamus and hippocampus may contribute to dysfunction within subcortical-cortical networks, consistent with previous evidence of metabolic and hemodynamic abnormalities in these regions in MDD.
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影响因子：
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