Ensembl 2023.
Ensembl 2023.
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DOI：
10.1093/nar/gkac958
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发表时间：
2023-01-06
影响因子：
14.9
通讯作者：
Flicek, Paul
中科院分区：
文献类型：
--
作者：
Martin, Fergal J.;Amode, M. Ridwan;Aneja, Alisha;Austine-Orimoloye, Olanrewaju;Azov, Andrey G.;Barnes, If;Becker, Arne;Bennett, Ruth;Berry, Andrew;Bhai, Jyothish;Bhurji, Simarpreet Kaur;Bignell, Alexandra;Boddu, Sanjay;Lins, Paulo R. Branco;Brooks, Lucy;Ramaraju, Shashank Budhanuru;Charkhchi, Mehrnaz;Cockburn, Alexander;Fiorretto, Luca Da Rin;Davidson, Claire;Dodiya, Kamalkumar;Donaldson, Sarah;El Houdaigui, Bilal;El Naboulsi, Tamara;Fatima, Reham;Giron, Carlos Garcia;Genez, Thiago;Ghattaoraya, Gurpreet S.;Martinez, Jose Gonzalez;Guijarro, Cristi;Hardy, Matthew;Hollis, Zoe;Hourlier, Thibaut;Hunt, Toby;Kay, Mike;Kaykala, Vinay;Le, Tuan;Lemos, Diana;Marques-Coelho, Diego;Marugan, Jose Carlos;Merino, Gabriela Alejandra;Mirabueno, Louisse Paola;Mushtaq, Aleena;Hossain, Syed Nakib;Ogeh, Denye N.;Sakthivel, Manoj Pandian;Parker, Anne;Perry, Malcolm;Pilizota, Ivana;Prosovetskaia, Irina;Perez-Silva, Jose G.;Salam, Ahamed Imran Abdul;Saraiva-Agostinho, Nuno;Schuilenburg, Helen;Sheppard, Dan;Sinha, Swati;Sipos, Botond;Stark, William;Steed, Emily;Sukumaran, Ranjit;Sumathipala, Dulika;Suner, Marie-Marthe;Surapaneni, Likhitha;Sutinen, Kyosti;Szpak, Michal;Tricomi, Francesca Floriana;Urbina-Gomez, David;Veidenberg, Andres;Walsh, Thomas A.;Walts, Brandon;Wass, Elizabeth;Willhoft, Natalie;Allen, Jamie;Alvarez-Jarreta, Jorge;Chakiachvili, Marc;Flint, Bethany;Giorgetti, Stefano;Haggerty, Leanne;Ilsley, Garth R.;Loveland, Jane E.;Moore, Benjamin;Mudge, Jonathan M.;Tate, John;Thybert, David;Trevanion, Stephen J.;Winterbottom, Andrea;Frankish, Adam;Hunt, Sarah E.;Ruffier, Magali;Cunningham, Fiona;Dyer, Sarah;Finn, Robert D.;Howe, Kevin L.;Harrison, Peter W.;Yates, Andrew D.;Flicek, Paul
Ensembl（https：//www.example.com）已经为脊椎动物和模式生物提供了20多年的高质量基因组资源。在此期间，我们的资源、服务和工具不断发展，与公开的基因组数据以及利用Ensembl平台的下游研究和应用保持一致。近年来，我们目睹了基因组格局的巨大变化。通过全球生物多样性倡议，高质量参考基因组的数量大幅增加。与此同时，在高等物种的泛基因组表达方面也取得了重大进展，其中现在可以获得代表不同品种、栽培品种、品系和单倍型的许多替代基因组组装。为了支持这些努力并加速下游研究，Ensembl的目标是为整个生命之树的物种创建高质量的注释，工具和服务。在这里，我们报告了我们的流行参考基因组资源，我们注释的急剧增长（包括来自第一个人类泛基因组图的单倍型），Ensembl变体效应预测器（VEP）的更新，AlphaFold DB的交互式蛋白质结构预测，以及我们新网站的beta版本。
Ensembl (https://www.ensembl.org) has produced high-quality genomic resources for vertebrates and model organisms for more than twenty years. During that time, our resources, services and tools have continually evolved in line with both the publicly available genome data and the downstream research and applications that utilise the Ensembl platform. In recent years we have witnessed a dramatic shift in the genomic landscape. There has been a large increase in the number of high-quality reference genomes through global biodiversity initiatives. In parallel, there have been major advances towards pangenome representations of higher species, where many alternative genome assemblies representing different breeds, cultivars, strains and haplotypes are now available. In order to support these efforts and accelerate downstream research, it is our goal at Ensembl to create high-quality annotations, tools and services for species across the tree of life. Here, we report our resources for popular reference genomes, the dramatic growth of our annotations (including haplotypes from the first human pangenome graphs), updates to the Ensembl Variant Effect Predictor (VEP), interactive protein structure predictions from AlphaFold DB, and the beta release of our new website.
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影响因子：
64.8
作者：
Bycroft C;Freeman C;Petkova D;Band G;Elliott LT;Sharp K;Motyer A;Vukcevic D;Delaneau O;O'Connell J;Cortes A;Welsh S;Young A;Effingham M;McVean G;Leslie S;Allen N;Donnelly P;Marchini J
通讯作者：
Marchini J
影响因子：
64.8
作者：
Jumper J;Evans R;Pritzel A;Green T;Figurnov M;Ronneberger O;Tunyasuvunakool K;Bates R;Žídek A;Potapenko A;Bridgland A;Meyer C;Kohl SAA;Ballard AJ;Cowie A;Romera-Paredes B;Nikolov S;Jain R;Adler J;Back T;Petersen S;Reiman D;Clancy E;Zielinski M;Steinegger M;Pacholska M;Berghammer T;Bodenstein S;Silver D;Vinyals O;Senior AW;Kavukcuoglu K;Kohli P;Hassabis D
通讯作者：
Hassabis D
DOI：
10.1126/science.1252806
发表时间：
2014-06-06
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Jiang Y;Xie M;Chen W;Talbot R;Maddox JF;Faraut T;Wu C;Muzny DM;Li Y;Zhang W;Stanton JA;Brauning R;Barris WC;Hourlier T;Aken BL;Searle SMJ;Adelson DL;Bian C;Cam GR;Chen Y;Cheng S;DeSilva U;Dixen K;Dong Y;Fan G;Franklin IR;Fu S;Guan R;Highland MA;Holder ME;Huang G;Ingham AB;Jhangiani SN;Kalra D;Kovar CL;Lee SL;Liu W;Liu X;Lu C;Lv T;Mathew T;McWilliam S;Menzies M;Pan S;Robelin D;Servin B;Townley D;Wang W;Wei B;White SN;Yang X;Ye C;Yue Y;Zeng P;Zhou Q;Hansen JB;Kristensen K;Gibbs RA;Flicek P;Warkup CC;Jones HE;Oddy VH;Nicholas FW;McEwan JC;Kijas J;Wang J;Worley KC;Archibald AL;Cockett N;Xu X;Wang W;Dalrymple BP
通讯作者：
Dalrymple BP
影响因子：
64.8
作者：
Armstrong J;Hickey G;Diekhans M;Fiddes IT;Novak AM;Deran A;Fang Q;Xie D;Feng S;Stiller J;Genereux D;Johnson J;Marinescu VD;Alföldi J;Harris RS;Lindblad-Toh K;Haussler D;Karlsson E;Jarvis ED;Zhang G;Paten B
通讯作者：
Paten B
影响因子：
14.9
作者：
Cezard T;Cunningham F;Hunt SE;Koylass B;Kumar N;Saunders G;Shen A;Silva AF;Tsukanov K;Venkataraman S;Flicek P;Parkinson H;Keane TM
通讯作者：
Keane TM