Runx1t1 promotes the neuronal differentiation in rat hippocampus
Runx1t1 promotes the neuronal differentiation in rat hippocampus
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Runx1t1促进大鼠海马神经元分化
DOI：
10.1186/s13287-020-01667-x
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发表时间：
2020-04
影响因子：
7.5
通讯作者：
Song Guoqi
中科院分区：
文献类型：
--
作者：
Zou Linqing;Li Haoming;Han Xiao;Qin Jianbing;Song Guoqi
研究背景Runx 1 t1是髓系易位基因家族的成员之一。我们的前期工作表明Runx 1 t1在体外可诱导放射状胶质细胞向神经元分化。方法为了更好地揭示Runx 1 t1在海马神经发生中的作用，本研究进一步探讨了Runx 1 t1在海马神经发生中的定位和功能。我们还发现，Runx 1 t1定位于神经元，而不是星形胶质细胞在体内和体外。此外，我们发现Runx 1 t1过表达增加了海马齿状回新生神经元的数量。ConclusionsTwo-together，我们的结果进一步证明Runx 1 t1可以作为海马神经发生过程中的调节器。
BackgroundRunt-related transcription factor 1 translocated to 1 (Runx1t1) is one of the members of the myeloid translocation gene family. Our previous work showed that Runx1t1 induced the neuronal differentiation of radial glia cells in vitro.MethodsTo better uncover the role of Runx1t1 in hippocampal neurogenesis, in this study, we further explore its localization and function during the hippocampal neurogenesis.ResultsOur results showed that insufficient expression of Runx1t1 reduced the neuronal differentiation, and overexpression of Runx1t1 promoted the neuronal differentiation in vitro. We also found that Runx1t1 localized in neurons but not astrocytes both in vivo and in vitro. Furthermore, we found that Runx1t1 overexpression elevated the number of newborn neurons in the hippocampal dentate gyrus.ConclusionsTaken together, our results further proved that Runx1t1 could be worked as a regulator in the process of hippocampal neurogenesis.
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通讯作者：
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影响因子：
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影响因子：
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