Discordance between responses of contrast echo intensity to increased flow rate in human coronary circulation and in vitro.
Discordance between responses of contrast echo intensity to increased flow rate in human coronary circulation and in vitro.
复制标题
对比回波强度对人体冠状循环和体外流速增加的反应之间的不一致。
DOI：
10.1016/0002-8703(92)90604-t
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发表时间：
1992
影响因子：
4.8
通讯作者：
A. L'Abbate
中科院分区：
文献类型：
--
作者：
D. Rovai;M. Lombardi;G. Ghelardini;M. Marzilli;L. Taddei;C. Michelassi;A. Distante;A. DeMaria;A. L'Abbate
根据斯图尔特-汉密尔顿方程，流量与可检测指示剂过境产生的时间-浓度曲线下的面积成反比。为了验证这一原理在声学造影术中的适用性，我们将糖回声造影剂(0.8ml)以不同的流速注入体外循环模型中。对二维回波图像进行数字化处理，得到视频强度随时间变化的曲线。不出所料，血流量与曲线下面积呈负相关(r=0.93)。为了将这一原理应用于人类冠状动脉循环，我们在6名患者的正常左冠状动脉内注射了声化碘帕米多(4ml)，在基线和静脉注射双嘧达莫(10分钟内0.84 mg/kg)之后。超声心动图数字化，绘制心肌时间-强度曲线。潘生丁给药后曲线下面积(210±128灰阶·秒)与基线时(177±80灰阶·秒)比较，差异无统计学意义。因此，在体外获得的对比回波数据与在人体冠脉循环中获得的对比回波数据之间存在不匹配。
According to the Stewart-Hamilton equation flow is inversely related to the area under the time-concentration curve produced by the transit of a detectable indicator. To verify the applicability of this principle for contrast echocardiography, we bolus injected a saccharide echo contrast agent (0.8 ml) into an in vitro circulatory model at variable flow rates. Two-dimensional echo images were digitized, and curves demonstrating the ratio of videointensity over time were derived. As expected, flow was inversely related to the area under the curves (r= 0.93). To apply this principle to human coronary circulation, we bolus injected sonicated iopamidol (4 ml) into the normal left coronary artery of six patients at baseline and after intravenous administration of dipyridamole (0.84 mg/kg in 10 minutes). Echo images were digitized, and myocardial time-intensity curves were derived. The area under the curve after dipyridamole administration (210 ± 128 gray level · sec) did not appear significantly different from that at baseline (177 ± 80 gray level · sec). Thus a mismatch exists between contrast echo data obtained in vitro and in human coronary circulation.
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人类心肌造影超声心动图：I. 安全性——与常规冠状动脉造影的比较。
影响因子：
24
作者：
Moore,CA;Smucker,ML;Kaul,S
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DOI：
10.1016/s0735-1097(84)80424-6
发表时间：
1984-01-01
影响因子：
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作者：
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影响因子：
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作者：
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通讯作者：
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影响因子：
24
作者：
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影响因子：
24
作者：
Kaul,S;Pandian,NG;Okada,RD;Pohost,GM;Weyman,AE
通讯作者：
Weyman,AE