Molecular epidemiological study of adenovirus infecting western lowland gorillas and humans in and around Moukalaba-Doudou National Park (Gabon).
Molecular epidemiological study of adenovirus infecting western lowland gorillas and humans in and around Moukalaba-Doudou National Park (Gabon).
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DOI：
10.1007/s11262-016-1360-8
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发表时间：
2016-10
期刊：
影响因子：
1.6
通讯作者：
Tsukiyama-Kohara, Kyoko
中科院分区：
文献类型：
--
作者：
Nkogue, Chimene Nze;Horie, Masayuki;Fujita, Shiho;Ogino, Michiko;Kobayashi, Yuki;Mizukami, Keijiro;Masatani, Tatsunori;Ezzikouri, Sayeh;Matsuu, Aya;Mizutani, Tetsuya;Ozawa, Makoto;Yamato, Osamu;Ngomanda, Alfred;Yamagiwa, Juichi;Tsukiyama-Kohara, Kyoko
腺病毒广泛存在于人类和类人猿中，但关于自然发生的腺病毒感染的数据仍然很少。我们在穆卡拉巴-杜杜国家公园（加蓬）的野生西部低地大猩猩中进行了腺病毒感染监测，以调查目标大猩猩中天然存在的腺病毒，并专门测试了居住在公园附近的当地人的可能的人畜共患传播。从西部低地大猩猩和人类收集粪便样品，并通过PCR进行分析。我们分别在大猩猩和居住在国家公园周围的当地人的样本中检测到腺病毒基因：大猩猩和人类的腺病毒总患病率分别为24. 1%和35. 0%。测序结果表明，在大猩猩体内检测到的腺病毒属于人肥大腺病毒B（HAdV-B B）、HAdV-C或HAdV-E，而在人类体内检测到的腺病毒属于HAdV-C或HAdV-D。虽然HAdV-C成员在大猩猩和人类中都被检测到，但系统发育分析显示，在大猩猩中检测到的病毒在遗传上与在人类中检测到的病毒不同。HAdV-C构成与宿主-病原体趋异相容的单一宿主谱系。然而，HAdV-B和HAdV-E由多个宿主谱系构成。此外，迄今为止没有证据表明存在人畜共患传染。由于腺病毒在大猩猩到人类之间的传播已经被证明，目前的监测应该在更广泛的范围内继续进行，以便对自然发生的腺病毒的自然历史有更多的了解，并对大猩猩种群进行安全管理。本文的在线版本（doi：10.1007/s11262-016-1360-8）包含补充材料，可供授权用户使用。
Adenoviruses are widespread in human population as well as in great apes, although the data about the naturally occurring adenovirus infections remain rare. We conducted the surveillance of adenovirus infection in wild western lowland gorillas in Moukalaba-Doudou National Park (Gabon), in order to investigate naturally occurring adenovirus in target gorillas and tested specifically a possible zoonotic transmission with local people inhabiting the vicinity of the park. Fecal samples were collected from western lowland gorillas and humans, and analyzed by PCR. We detected adenoviral genes in samples from both gorillas and the local people living around the national park, respectively: the overall prevalence rates of adenovirus were 24.1 and 35.0 % in gorillas and humans, respectively. Sequencing revealed that the adenoviruses detected in the gorillas were members of Human mastadenovirus B (HAdV-B), HAdV-C, or HAdV-E, and those in the humans belonged to HAdV-C or HAdV-D. Although HAdV-C members were detected in both gorillas and humans, phylogenetic analysis revealed that the virus detected in gorillas are genetically distinct from those detected in humans. The HAdV-C constitutes a single host lineage which is compatible with the host-pathogen divergence. However, HAdV-B and HAdV-E are constituted by multiple host lineages. Moreover, there is no evidence of zoonotic transmission thus far. Since the gorilla-to-human transmission of adenovirus has been shown before, the current monitoring should be continued in a broader scale for getting more insights in the natural history of naturally occurring adenoviruses and for the safe management of gorillas’ populations. The online version of this article (doi:10.1007/s11262-016-1360-8) contains supplementary material, which is available to authorized users.
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影响因子：
3.7
作者：
Seimon TA;Olson SH;Lee KJ;Rosen G;Ondzie A;Cameron K;Reed P;Anthony SJ;Joly DO;Karesh WB;McAloose D;Lipkin WI
通讯作者：
Lipkin WI
影响因子：
4.8
作者：
Wevers D;Leendertz FH;Scuda N;Boesch C;Robbins MM;Head J;Ludwig C;Kühn J;Ehlers B
通讯作者：
Ehlers B
影响因子：
2.7
作者：
Lehmkuhl, Howard D.;Hobbs, L. A.
通讯作者：
Hobbs, L. A.
影响因子：
64.8
作者：
ROGERS, NG;BASNIGHT, M;GAJDUSEK, DC
通讯作者：
GAJDUSEK, DC
影响因子：
4.6
作者：
Robinson, Christopher M.;Singh, Gurdeep;Lee, Jeong Yoon;Dehghan, Shoaleh;Rajaiya, Jaya;Liu, Elizabeth B.;Yousuf, Mohammad A.;Betensky, Rebecca A.;Jones, Morris S.;Dyer, David W.;Seto, Donald;Chodosh, James
通讯作者：
Chodosh, James