Influences of 12-Week Physical Activity Interventions on TMS Measures of Cortical Network Inhibition and Upper Extremity Motor Performance in Older Adults-A Feasibility Study.
Influences of 12-Week Physical Activity Interventions on TMS Measures of Cortical Network Inhibition and Upper Extremity Motor Performance in Older Adults-A Feasibility Study.
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DOI：
10.3389/fnagi.2017.00422
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发表时间：
2017
影响因子：
4.8
通讯作者：
Nocera JR
中科院分区：
文献类型：
--
作者：
McGregor KM;Crosson B;Mammino K;Omar J;García PS;Nocera JR
目的：先前横断面研究的数据表明，身体健康水平的提高与一生中运动灵活性的提高有关。此外，身体健康与单手任务中皮质功能偏侧性的增加呈正相关；这表明久坐衰老与影响运动表现的大脑半球间抑制的丧失有关。本研究对以前久坐不动的老年人进行了运动干预，以比较运动灵活性和干预后使用经颅磁刺激(TMS)测量的大脑半球间抑制。方法：21名居住在社区、据称久坐不动的老年人被随机纳入12周有氧运动组或12周非有氧运动平衡状态。有氧运动包括间歇性自行车“旋转”活动，而非有氧“平衡”运动包括平衡和伸展运动。参与者在研究干预前后的单独评估会议上完成了上肢灵巧性电池和最大摄氧量的估计，并在单独的评估会议上接受了单脉冲(同侧静默期-ISP)和成对脉冲大脑半球间抑制(PpIHI)。在连续记录心率以测量运动水平(负荷)的每次干预之后，参与者交叉进入研究的备用手臂，在AB/BA设计中额外进行12周的干预期，没有冲洗期。结果：干预后，无论干预顺序如何，在有氧旋转状态下的参与者在干预12周后显示出比非有氧平衡干预中的估计VO2max更高的估计VO2max水平。由于研究设计的原因，在控制了结转效应后，旋转状态下的参与者表现出比平衡状态下更长的isp持续时间。在旋转状态后，心率负荷与静止期持续时间的相关性比估计的VO2更强。结论：当使用isp进行评估时，12周的体力活动干预可能会影响与年龄相关的皮质抑制的变化。尽管抑制性信号在ppIHI和isp测量中起中介作用，但每种TMS通道都可能使用不同的抑制性网络，可能会受到年龄的不同影响。体力活动干预后抑制功能的变化可能与灵巧性和运动控制力的提高有关，至少这项可行性研究的证据表明。
Objective: Data from previous cross-sectional studies have shown that an increased level of physical fitness is associated with improved motor dexterity across the lifespan. In addition, physical fitness is positively associated with increased laterality of cortical function during unimanual tasks; indicating that sedentary aging is associated with a loss of interhemispheric inhibition affecting motor performance. The present study employed exercise interventions in previously sedentary older adults to compare motor dexterity and measure of interhemispheric inhibition using transcranial magnetic stimulation (TMS) after the interventions. Methods: Twenty-one community-dwelling, reportedly sedentary older adults were recruited, randomized and enrolled to a 12-week aerobic exercise group or a 12-week non-aerobic exercise balance condition. The aerobic condition was comprised of an interval-based cycling “spin” activity, while the non-aerobic “balance” exercise condition involved balance and stretching activities. Participants completed upper extremity dexterity batteries and estimates of VO2max in addition to undergoing single (ipsilateral silent period—iSP) and paired-pulse interhemispheric inhibition (ppIHI) in separate assessment sessions before and after study interventions. After each intervention during which heart rate was continuously recorded to measure exertion level (load), participants crossed over into the alternate arm of the study for an additional 12-week intervention period in an AB/BA design with no washout period. Results: After the interventions, regardless of intervention order, participants in the aerobic spin condition showed higher estimated VO2max levels after the 12-week intervention as compared to estimated VO2max in the non-aerobic balance intervention. After controlling for carryover effects due to the study design, participants in the spin condition showed longer iSP duration than the balance condition. Heart rate load was more strongly correlated with silent period duration after the Spin condition than estimated VO2. Conclusions: Aging-related changes in cortical inhibition may be influenced by 12-week physical activity interventions when assessed with the iSP. Although inhibitory signaling is mediates both ppIHI and iSP measures each TMS modality likely employs distinct inhibitory networks, potentially differentially affected by aging. Changes in inhibitory function after physical activity interventions may be associated with improved dexterity and motor control at least as evidence from this feasibility study show.
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DOI：
10.1097/nrl.0b013e3181b1d5b0
发表时间：
2010-07
期刊：
The neurologist
影响因子：
--
作者：
Hill BD;Barkemeyer CA;Jones GN;Santa Maria MP;Minor KS;Browndyke JN
通讯作者：
Browndyke JN
影响因子：
2.4
作者：
Davidson T;Tremblay F
通讯作者：
Tremblay F
最佳数量的脉冲数量作为神经腔内颅磁刺激的结果度量。
DOI：
10.1016/j.clinph.2016.04.001
发表时间：
2016-08
期刊：
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
影响因子：
--
作者：
Chang WH;Fried PJ;Saxena S;Jannati A;Gomes-Osman J;Kim YH;Pascual-Leone A
通讯作者：
Pascual-Leone A
影响因子：
11
作者：
Hanna-Pladdy, B;Mendoza, JE;Heilman, KM
通讯作者：
Heilman, KM
影响因子：
3.4
作者：
Jung, Patrick;Ziemann, Ulf
通讯作者：
Ziemann, Ulf