Vasotrophic regulation of age-dependent hypoxic cerebrovascular remodeling.
Vasotrophic regulation of age-dependent hypoxic cerebrovascular remodeling.
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DOI：
10.2174/1570161111311050002
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发表时间：
2013-09
影响因子：
4.5
通讯作者：
Pearce WJ
中科院分区：
文献类型：
--
作者：
Silpanisong J;Pearce WJ
缺氧可通过改变营养因子的表达，促进体内平衡，从而诱导血管功能和结构重建。虽然大多数实验方法都集中在功能重塑，但结构重塑可以反映决定功能重塑的血管蛋白质丰度和组织的变化。更好地了解年龄依赖性缺氧性脑血管重构过程及其临床意义需要了解影响动脉结构和功能的血管营养因子。缺氧可影响转录因子、经典受体酪氨酸激酶因子、非经典G蛋白偶联因子、儿茶酚胺和嘌呤的表达。低氧的重塑作用可以通过大多数血管床中的低氧诱导因子（HIF）上调来介导，但是生长因子表达的改变也可以独立于HIF。过氧化物酶体增殖物激活受体γ是另一个参与低氧性重构的转录因子。经典受体酪氨酸激酶配体（包括血管内皮生长因子、血小板衍生生长因子、成纤维细胞生长因子和血管生成素）的表达可通过缺氧改变，缺氧可同时作用以影响重塑。酪氨酸激酶非依赖性因子，如转化生长因子、一氧化氮、内皮素、血管紧张素II、儿茶酚胺和嘌呤也参与重塑过程。这种对缺氧应激的适应会随着年龄的增长而发生根本性的变化，从而导致胎儿和成人之间的不同反应。总体而言，这些机制整合以确保血流和代谢需求在所有血管床中紧密匹配，并强调血管壁是高度动态和异质组织，具有经历规律表型转化的多种细胞类型。
Hypoxia can induce functional and structural vascular remodeling by changing the expression of trophic factors to promote homeostasis. While most experimental approaches have been focused on functional remodeling, structural remodeling can reflect changes in the abundance and organization of vascular proteins that determine functional remodeling. Better understanding of age-dependent hypoxic macrovascular remodeling processes of the cerebral vasculature and its clinical implications require knowledge of the vasotrophic factors that influence arterial structure and function. Hypoxia can affect the expression of transcription factors, classical receptor tyrosine kinase factors, non-classical G-protein coupled factors, catecholamines, and purines. Hypoxia’s remodeling effects can be mediated by Hypoxia Inducible Factor (HIF) upregulation in most vascular beds, but alterations in the expression of growth factors can also be independent of HIF. PPARγ is another transcription factor involved in hypoxic remodeling. Expression of classical receptor tyrosine kinase ligands, including vascular endothelial growth factor, platelet derived growth factor, fibroblast growth factor and angiopoietins, can be altered by hypoxia which can act simultaneously to affect remodeling. Tyrosine kinase-independent factors, such as transforming growth factor, nitric oxide, endothelin, angiotensin II, catecholamines, and purines also participate in the remodeling process. This adaptation to hypoxic stress can fundamentally change with age, resulting in different responses between fetuses and adults. Overall, these mechanisms integrate to assure that blood flow and metabolic demand are closely matched in all vascular beds and emphasize the view that the vascular wall is a highly dynamic and heterogeneous tissue with multiple cell types undergoing regular phenotypic transformation.
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影响因子：
20.1
作者：
BEVAN, RD;TSURU, H
通讯作者：
TSURU, H
血管内皮生长因子可以通过血小板衍生的生长因子受体发出信号。
影响因子：
7.8
作者：
Ball, Stephen G;Shuttleworth, C Adrian;Kielty, Cay M
通讯作者：
Kielty, Cay M
DOI：
10.1164/ajrccm.158.6.9804076
发表时间：
1998-12-01
影响因子：
24.7
作者：
Berg, JT;Breen, EC;West, JB
通讯作者：
West, JB
DOI：
10.1152/ajpheart.2001.281.3.h1163
发表时间：
2001-09-01
影响因子：
4.8
作者：
Amaral, SL;Papanek, PE;Greene, AS
通讯作者：
Greene, AS
影响因子：
20.1
作者：
Asahara, T;Chen, DH;Isner, JM
通讯作者：
Isner, JM