Minocycline modulates human social decision-making: possible impact of microglia on personality-oriented social behaviors.
Minocycline modulates human social decision-making: possible impact of microglia on personality-oriented social behaviors.
复制标题
DOI：
10.1371/journal.pone.0040461
复制
发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Kanba S
中科院分区：
文献类型：
--
作者：
Kato TA;Watabe M;Tsuboi S;Ishikawa K;Hashiya K;Monji A;Utsumi H;Kanba S
小胶质细胞是神经胶质细胞的一种，在包括精神疾病在内的各种脑病理中发挥重要作用。此外，最近已经证明，即使在正常大脑中，小胶质细胞也可以通过直接接触来监测突触反应。人类小胶质细胞可以调节各种社会/心理功能，而小胶质细胞的社会/心理作用仍然没有得到解决，特别是在健康的人。没有已知的药物具有调节小胶质细胞的特异性作用。因此，使用四环素类抗生素和最著名的小胶质细胞抑制剂米诺环素是阐明小胶质细胞在人类社会/心理活动中的功能的最佳替代方法之一。我们进行了一项信任游戏的双盲随机试验，这是一项货币决策实验，99名成年男性在服用米诺环素4天后决定对匿名伴侣的信任程度。我们以前的试点试验表明米诺环素的积极作用，但其潜在的机制尚未阐明。因此，在这项样本量较大的试验中，我们还测量了焦虑和个性的影响。二甲胺四环素组信任游戏中的金钱得分显著较低。有趣的是，参与者的决策方式发生了显着变化;合作性，人格的一个组成部分，被证明是安慰剂组决策的主要调节因素，另一方面，二甲胺四环素组主要受状态焦虑和信任的调节。我们的研究结果表明，米诺环素导致更多的情况为导向的决策，可能通过抑制人格特质的影响，此外，人格和社会行为可能是由小胶质细胞调制。早期生活事件可以激活人类小胶质细胞，建立某种神经突触连接，并且这种形成可以决定每个人在以后生活中的个性和以个性为导向的社会行为。为了探索这些机制，需要进一步的转化研究。UMIN临床试验中心UMIN 000004803
Microglia, one of the glial cells, play important roles in various brain pathologies including psychiatric disorders. In addition, microglia have recently been proved to monitor synaptic reactions via direct-touching even in normal brain. Human microglia may modulate various social/mental functions, while microglial social/mental roles remain unresolved especially in healthy humans. There is no known drug with the specific effect of modulating microglia. Therefore, using minocycline, a tetracycline antibiotic and the most famous microglial inhibitor, is one of the best alternative approaches to clarify microglial functions on human social/mental activities. We conducted a double-blind randomized trial of trust game, a monetary decision-making experiment, with ninety-nine human adult males who decided how much to trust an anonymous partner after a four-day administration of minocycline. Our previous pilot trial indicated a positive effect of minocycline, while the underlying mechanisms were not clarified. Therefore, in this trial with larger samples, we additionally measured the effects of anxiety and personality. The monetary score in trust game was significantly lower in the minocycline group. Interestingly, participants’ ways of decision-making were significantly shifted; cooperativeness, one component of personality, proved to be the main modulating factor of decision-making in the placebo group, on the other hand, the minocycline group was mainly modulated by state anxiety and trustworthiness. Our results suggest that minocycline led to more situation-oriented decision-making, possibly by suppressing the effects of personality traits, and furthermore that personality and social behaviors might be modulated by microglia. Early-life events may activate human microglia, establish a certain neuro-synaptic connection, and this formation may determine each human’s personality and personality- oriented social behaviors in later life. To explore these mechanisms, further translational research is needed. UMIN clinical trial center UMIN000004803
登录
查看更多内容
影响因子：
4.5
作者：
Kato, Takahiro;Monji, Akira;Kanba, Shigenobu
通讯作者：
Kanba, Shigenobu
影响因子：
4.7
作者：
Kato, Takahiro;Mizoguchi, Yoshito;Kanba, Shigenobu
通讯作者：
Kanba, Shigenobu
影响因子：
64.8
作者：
Kosfeld, M;Heinrichs, M;Fehr, E
通讯作者：
Fehr, E
影响因子：
2.3
作者：
Kijima, N;Tanaka, E;Kitamura, T
通讯作者：
Kitamura, T
影响因子：
3
作者：
Bilbo SD;Schwarz JM
通讯作者：
Schwarz JM