Zinc supplement use and risk of aggressive prostate cancer: a 30-year follow-up study.
Zinc supplement use and risk of aggressive prostate cancer: a 30-year follow-up study.
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DOI：
10.1007/s10654-022-00922-0
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发表时间：
2022-12
影响因子：
13.6
通讯作者：
Giovannucci, Edward L.
中科院分区：
文献类型：
--
作者：
Zhang, Yiwen;Song, Mingyang;Mucci, Lorelei A.;Giovannucci, Edward L.
补充锌被认为具有治疗前列腺癌的潜力，但它对前列腺癌发病率的影响，特别是高剂量，是有争议的。从1986年到2016年，共有47240名来自健康专业人员后续研究的男性接受了跟踪调查。男性报告了他们在基线时和之后每两年补充一次锌的情况。前列腺癌的临床特征包括分期、分级、致死性和侵袭性(T4或N1或M1或Gleason 8-10)。多变量COX比例风险模型用于评估补锌与前列腺癌发病率之间的关系。在28.3年的中位数随访中，我们记录了6980例前列腺癌病例，其中1053例是致死性的，1143例是侵袭性的。锌补充剂的使用与整体的、局部的、低级别和中等级别前列腺癌无关。然而，与从不服用锌的男性相比，每天补充锌超过75 mg的男性患致命(HR：1.76，95%CI：1.16~2.66，P趋势=0.001)和侵袭性前列腺癌(HR：1.8，95%CI：1.19~2.73，P趋势=0.006)的风险更高。同样，补充锌15年或以上的男性患致命(HR：1.91，95%CI：1.28-2.85，P趋势=0.001)和侵袭性前列腺癌(HR：1.55，95%CI：1.03-2.33，P趋势=0.004)的风险更高。每天超过75毫克或超过15年的锌补充量可能会大大增加患致命和侵袭性前列腺癌的风险。在成年男性中过量使用锌补充剂是值得注意的。网上版载有补充材料，可在10.1007/s10654-022-00922-0查阅。
Zinc supplementation was hypothesized to have therapeutic potential against prostate cancer, but its influence on prostate cancer incidence especially at high doses is controversial. A total of 47,240 men from the Health Professionals Follow-up Study were followed from 1986 to 2016. Men reported their zinc supplement use at baseline and biennially thereafter. Clinical features of prostate cancer included stage, grade, lethal and aggressive (T4 or N1 or M1 or Gleason 8–10) outcome. Multivariable Cox proportional hazards models were used to evaluate the association between zinc supplement use and incidence of prostate cancer. During a median follow-up of 28.3 years, we documented 6,980 incident prostate cancer cases including 1,053 lethal and 1,143 aggressive. Zinc supplement use was not associated with overall, localized, low- and intermediate-grade prostate cancer. However, compared to never-users, men who used supplement zinc more than 75 mg/day were at higher risk for lethal (HR: 1.76, 95% CI: 1.16–2.66, Ptrend = 0.001) and aggressive prostate cancer (HR: 1.80, 95% CI: 1.19–2.73, Ptrend = 0.006). Similarly, men who took supplemental zinc for 15 or more years had a higher risk for lethal (HR: 1.91, 95% CI: 1.28–2.85, Ptrend <0.001) and aggressive prostate cancer (HR: 1.55, 95% CI: 1.03–2.33, Ptrend = 0.004). Zinc supplementation of more than 75 mg per day or over 15 years may substantially increase risk of lethal and aggressive prostate cancer. Caution is warranted regarding excessive usage of zinc supplements among adult men. The online version contains supplementary material available at 10.1007/s10654-022-00922-0.
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