Behaviourally modulated hippocampal theta oscillations in the ferret persist during both locomotion and immobility.
Behaviourally modulated hippocampal theta oscillations in the ferret persist during both locomotion and immobility.
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DOI：
10.1038/s41467-022-33507-2
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发表时间：
2022-10-07
影响因子：
16.6
通讯作者：
中科院分区：
文献类型：
--
作者：
Theta 振荡是哺乳动物海马活动的标志，在许多记忆和空间导航的海马模型中发挥着关键作用。为了协调在 θ 的存在和特性中观察到的跨物种差异，我们记录了大鼠和雪貂在旨在改变运动和感觉注意力的听觉和视觉定位任务期间的海马局部场电位。在这里，我们发现雪貂和大鼠在运动过程中都会发生 θ 振荡，但是在不动期间，雪貂中仍存在 θ 振荡，这与大鼠中转向大不规则活动 (LIA) 形成鲜明对比。雪貂不动期间的 Theta 被认为类似于在啮齿类动物中观察到的 2 型 theta，因为它对阿托品敏感，并且受到行为状态的调节，在奖励时期观察到最强的 theta。这些结果表明，即使在相似的行为条件下，物种之间的θ和行为状态之间的关系也存在差异。跨物种研究是充分了解大脑功能的关键。在这里，作者将雪貂作为海马研究的一个物种，并表明，与老鼠形成鲜明对比的是，雪貂在不动时具有强烈的 θ 振荡。
Theta oscillations are a hallmark of hippocampal activity across mammals and play a critical role in many hippocampal models of memory and spatial navigation. To reconcile the cross-species differences observed in the presence and properties of theta, we recorded hippocampal local field potentials in rats and ferrets during auditory and visual localisation tasks designed to vary locomotion and sensory attention. Here, we show that theta oscillations occur during locomotion in both ferrets and rats, however during periods of immobility, theta oscillations persist in the ferret, contrasting starkly with the switch to large irregular activity (LIA) in the rat. Theta during immobility in the ferret is identified as analogous to Type 2 theta that has been observed in rodents due to its sensitivity to atropine, and is modulated by behavioural state with the strongest theta observed during reward epochs. These results demonstrate that even under similar behavioural conditions, differences exist between species in the relationship between theta and behavioural state. Cross-species research is key to fully understanding brain function. Here, the authors present the ferret as a species for hippocampal research and show that, in stark contrast to rats, ferrets have robust theta oscillations during immobility.
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影响因子：
16.2
作者：
Bush D;Barry C;Manson D;Burgess N
通讯作者：
Burgess N
影响因子：
16.2
作者：
Buzsáki G;Logothetis N;Singer W
通讯作者：
Singer W
DOI：
10.1016/0013-4694(79)90011-7
发表时间：
1979-01-01
期刊：
ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY
影响因子：
--
作者：
ARNOLDS, DEAT;LOPESDASILVA, FH;KAMP, A
通讯作者：
KAMP, A
DOI：
10.1523/jneurosci.4122-11.2012
发表时间：
2012-01-11
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Belluscio MA;Mizuseki K;Schmidt R;Kempter R;Buzsáki G
通讯作者：
Buzsáki G
影响因子：
9.8
作者：
Courellis, Hristos S.;Nummela, Samuel U.;Miller, Cory T.
通讯作者：
Miller, Cory T.