Fear induced neuronal alterations in a genetic model of depression: an fMRI study on awake animals.
Fear induced neuronal alterations in a genetic model of depression: an fMRI study on awake animals.
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DOI：
10.1016/j.neulet.2010.11.069
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发表时间：
2011-02-04
影响因子：
2.5
通讯作者：
King JA
中科院分区：
文献类型：
--
作者：
Huang W;Heffernan ME;Li Z;Zhang N;Overstreet DH;King JA
以前的人类成像研究使用面部刺激来探索抑郁和恐惧之间的潜在联系。本研究旨在研究当捕食者气味三甲基噻唑啉（TMT）诱发先天恐惧时，啮齿动物抑郁模型的大脑变化。采用抑郁症遗传动物模型弗林德斯敏感系大鼠（FSL）及其对照弗林德斯抗性系大鼠（FRL）进行功能磁共振成像（fMRI）评估。与FRL相比，FSL大鼠在TMT反应中表现出更大的皮层杏仁核BOLD激活和前额叶皮层低激活，表明抑郁品系存在皮质-杏仁核功能障碍。此外，FSL大鼠岛叶皮质的过度激活可能是抑郁症中神经元对恐惧和厌恶反应增强的基础。这些结果证明了抑郁症的翻译模型在扩大对神经回路的理解方面的价值，这些神经回路服务于抑郁症和恐惧等常见的人类合并症。
Previous human imaging studies used facial stimuli to explore the potential association between depression and fear. This study aimed at investigating brain alterations in a rodent model of depression when innate fear was induced in the form of the predator odor trimethylthiazoline (TMT). Flinders sensitive line rats (FSL), a genetic animal model of depression, and their control counterpart Flinders resistant line (FRL), were used in this functional magnetic resonance imaging (fMRI) assessment. Compared to FRL, FSL rats exhibited greater BOLD activation in the cortical amygdala and hypoactivation in the prefrontal cortex in response to TMT, suggesting cortico-amygdalar dysfunction in the depressed strain. In addition, the hyperactivation in the insular cortex in FSL rats may be the basis for enhanced neuronal responses to fear and aversion in depression. These results are evidence for the value of translational models of depression in expanding understanding of the neural circuitries sub-serving common human co-morbidities like depression and fear.
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