Female fear: influence of estrus cycle on behavioral response and neuronal activation.
Female fear: influence of estrus cycle on behavioral response and neuronal activation.
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DOI：
10.1016/j.bbr.2009.01.019
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发表时间：
2009-07-19
影响因子：
2.7
通讯作者：
King, Jean A.
中科院分区：
文献类型：
--
作者：
Chen, Wei;Shields, Jessica;Huang, Wei;King, Jean A.
我们观察到雄性大鼠的先天恐惧反应与激素状态不同，以及人类女性中恐惧和焦虑障碍的较高患病率，从而导致了目前对发情周期阶段对先天恐惧反应的影响的研究。在不同的周期阶段，雌性大鼠暴露于先天恐惧诱导刺激（2,5-二氢- 2,4,5-三甲基噻唑啉，TMT气味），并监测其行为和大脑激活的变化。行为学数据显示，与周期的其他阶段相比，发情期间对TMT的冻结反应显着增强。与发情前和发情期相比，发情期皮层和皮层下区域的像素强度显著增加，这一数据得到了支持。成像结果显示，当比较发情和断情时，躯体感觉和岛叶皮层的大脑活动显著增加。与发情前相比，发情期的中隔神经活动明显增加。此外，海马体、下丘脑、嗅觉系统和扣带皮层在发情期比发情期和发情前期都有显著的增加。综上所述，这些结果表明，女性的荷尔蒙状态可能与恐惧的神经元和行为指标的改变有关。
Our observation that male rats innate fear response differed with hormonal status, as well as the higher prevalence of fear and anxiety disorders in human females led to the current investigation of the impact of phases of the estrous cycle on innate fear responding. Female rats in different phases of the cycle were exposed to an innate fear-inducing stimulus (2,5-dihydro- 2,4,5-trimethylthiazoline, TMT odor) and monitored for changes in behavior and brain activation. Behavioral data showed freezing responses to TMT were significantly enhanced during estrus as compared to other phases of the cycle. This data was supported by significant increases in pixel intensity in cortical and sub-cortical regions in estrus compared to proestrus and diestrus. Imaging results demonstrated significant increases in brain activation in the somatosensory and insular cortices when comparing estrus to diestrus. There were significant increases in neural activity in the BNST and septum in estrus as compared to proestrus. Additionally, the hippocampus, hypothalamus, olfactory system, and cingulate cortex show significant increases in the estrus phase when compared to both diestrus and proestrus. Taken together, these results suggest that the female's hormonal status may be correlated with alterations in both neuronal and behavioral indices of fear.
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影响因子：
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通讯作者：
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