MR elastography frequency-dependent and independent parameters demonstrate accelerated decrease of brain stiffness in elder subjects.
MR elastography frequency-dependent and independent parameters demonstrate accelerated decrease of brain stiffness in elder subjects.
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DOI：
10.1007/s00330-020-07054-7
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发表时间：
2020-12
影响因子：
5.9
通讯作者：
Wintermark M
中科院分区：
文献类型：
--
作者：
Lv H;Kurt M;Zeng N;Ozkaya E;Marcuz F;Wu L;Laksari K;Camarillo DB;Pauly KB;Wang Z;Wintermark M
分析26 ~ 76岁健康成人大脑不同区域的力学特性。采用多频磁共振弹性成像（MRE）方法，分析了年龄对46名健康男性和女性脑实质、皮质灰质（GM）、白质（WM）和皮质下GM结构的频率相关参数（存储模量G′和损失模量G′）和频率无关参数（μ1、μ2和η，由标准线性实体模型确定）的影响。对不同年龄组的大脑多频行为和频率无关参数进行了分析。脑实质、皮质GM和WM的G′年变化率为- 0.32% ~ - 0.36%，G′年变化率为- 0.43% ~ - 0.55%。皮质下GM的G′变化范围为- 0.18% ~ - 0.23%，G′变化范围为- 0.43%。有趣的是，在皮质下GM的某些区域，男性表现出弹性下降，而女性表现出黏度下降。在60岁以上的受试者中，黏度也显著下降。60 Hz时的G′和G”值以及尾状核、壳核和丘脑的频率无关μ2值可以作为表征衰老对大脑影响的参数。老年受试者大脑僵硬度的下降速度加快。
To analyze the mechanical properties in different regions of the brain in healthy adults in a wide age range: 26 to 76 years old. We used a multifrequency magnetic resonance elastography (MRE) protocol to analyze the effect of age on frequency-dependent (storage and loss moduli, G’ and G”, respectively) and frequency-independent parameters (μ1, μ2 and η, as determined by a standard linear solid model) of the cerebral parenchyma, cortical gray matter (GM), white matter (WM) and subcortical GM structures of 46 healthy male and female subjects. The multifrequency behavior of the brain and frequency-independent parameters were analyzed across different age groups. The annual change rate ranged from −0.32% to −0.36% for G’ and −0.43% to −0.55% for G” for the cerebral parenchyma, cortical GM and WM. For the subcortical GM, changes in G’ ranged from −0.18% to −0.23%, and G” changed −0.43%. Interestingly, males exhibited decreased elasticity, while females exhibited decreased viscosity with respect to age in some regions of subcortical GM. Significantly decreased values were also found in subjects over 60 years old. Values of G’ and G” at 60 Hz and the frequency-independent μ2 of the caudate, putamen and thalamus may serve as parameters that characterize the aging effect on the brain. The decrease in brain stiffness accelerates in elderly subjects.
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影响因子：
5.7
作者：
Murphy MC;Huston J 3rd;Ehman RL
通讯作者：
Ehman RL
影响因子：
4.2
作者：
Hiscox LV;Johnson CL;McGarry MDJ;Perrins M;Littlejohn A;van Beek EJR;Roberts N;Starr JM
通讯作者：
Starr JM
整个阿尔茨海默氏病谱系中的区域大脑僵硬变化。
DOI：
10.1016/j.nicl.2015.12.007
发表时间：
2016
期刊：
NeuroImage. Clinical
影响因子：
--
作者：
Murphy MC;Jones DT;Jack CR Jr;Glaser KJ;Senjem ML;Manduca A;Felmlee JP;Carter RE;Ehman RL;Huston J 3rd
通讯作者：
Huston J 3rd
通过磁共振弹性成像确定阿尔茨海默氏病的大脑硬度降低。
影响因子：
4.4
作者：
Murphy, Matthew C.;Huston, John, III;Jack, Clifford R., Jr.;Glaser, Kevin J.;Manduca, Armando;Felmlee, Joel P.;Ehman, Richard L.
通讯作者：
Ehman, Richard L.
影响因子：
5
作者：
ElSheikh, Mona;Arani, Arvin;Huston, John, III
通讯作者：
Huston, John, III