The Hydric Environment: A Hub for Clinically Relevant Carbapenemase Encoding Genes.
The Hydric Environment: A Hub for Clinically Relevant Carbapenemase Encoding Genes.
复制标题
DOI：
10.3390/antibiotics9100699
复制
发表时间：
2020-10-15
期刊：
影响因子：
--
通讯作者：
Licznar-Fajardo P
中科院分区：
文献类型：
--
作者：
Hammer-Dedet F;Jumas-Bilak E;Licznar-Fajardo P
碳青霉烯类抗生素是一种β-内酰胺类抗菌药物，具有广泛的抗菌活性，被认为是最后的抗生素。自本世纪初以来，产生碳青霉烯酶肠杆菌(CPE)并迅速在全球范围内传播。碳青霉烯酶编码基因(CEG)在临床相关细菌中的全球传播部分归因于其在可移动遗传元件上的位置。在过去的十年中，产生碳青霉烯酶的细菌已经从包括水环境在内的非人类来源中分离出来。水生态系统尤其受到人类活动的影响，人类活动促成了水环境与人类之间的双向交流，因此水环境可能构成CPE和CEG的枢纽。最近，有报道分离到携带获得性CEG的自生水生细菌，这表明同种异体细菌和自体细菌之间通过水平基因转移进行了CEG交换。因此，水环境对CEG在环境生态系统和人类中的持续、传播和出现起着核心作用，值得特别关注。
Carbapenems are β-lactams antimicrobials presenting a broad activity spectrum and are considered as last-resort antibiotic. Since the 2000s, carbapenemase producing Enterobacterales (CPE) have emerged and are been quickly globally spreading. The global dissemination of carbapenemase encoding genes (CEG) within clinical relevant bacteria is attributed in part to its location onto mobile genetic elements. During the last decade, carbapenemase producing bacteria have been isolated from non-human sources including the aquatic environment. Aquatic ecosystems are particularly impacted by anthropic activities, which conduce to a bidirectional exchange between aquatic environments and human beings and therefore the aquatic environment may constitute a hub for CPE and CEG. More recently, the isolation of autochtonous aquatic bacteria carrying acquired CEG have been reported and suggest that CEG exchange by horizontal gene transfer occurred between allochtonous and autochtonous bacteria. Hence, aquatic environment plays a central role in persistence, dissemination and emergence of CEG both within environmental ecosystem and human beings, and deserves to be studied with particular attention.
登录
查看更多内容
影响因子：
5.2
作者：
Falgenhauer, Linda;Schwengers, Oliver;Imirzalioglu, Can
通讯作者：
Imirzalioglu, Can
影响因子：
11.8
作者：
Falagas ME;Tansarli GS;Karageorgopoulos DE;Vardakas KZ
通讯作者：
Vardakas KZ
影响因子：
4.9
作者：
Carrer, Amelie;Poirel, Laurent;Nordmann, Patrice
通讯作者：
Nordmann, Patrice
影响因子：
--
作者：
Chouchani, Chedly;Marrakchi, Rim;Correia, Antonio
通讯作者：
Correia, Antonio
影响因子：
6.9
作者：
Baranovsky, S.;Jumas-Bilak, E.;Romano-Bertrand, S.
通讯作者：
Romano-Bertrand, S.