Pediatric neuroimaging using magnetic resonance imaging during non-sedated sleep.
Pediatric neuroimaging using magnetic resonance imaging during non-sedated sleep.
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DOI：
10.1007/s00247-013-2752-8
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发表时间：
2014-01
影响因子：
2.3
通讯作者：
Deoni, Sean C. L.
中科院分区：
文献类型：
--
作者：
Dean, Douglas C., III;Dirks, Holly;O'Muircheartaigh, Jonathan;Walker, Lindsay;Jerskey, Beth A.;Lehman, Katie;Han, Michelle;Waskiewicz, Nicole;Deoni, Sean C. L.
许多神经和精神疾病的病因学研究越来越多地转向对婴儿大脑发育的纵向研究，以便在出现明显的临床症状之前识别诱因的结构和/或功能差异。虽然MRI为了解发育中的大脑提供了一个非侵入性的窗口，但婴儿和蹒跚学步的儿童的MRI是具有挑战性的，因为这种模式的极端运动敏感性以及儿童在图像采集过程中很难保持静止。在这里，我们概述了4岁以下儿童在自然、非镇静睡眠中成功进行MRI的广泛研究方案。所有的孩子都是在自然的、非镇静的睡眠中进行成像的。采取了主动和被动措施来降低噪声，以减少儿童在获取过程中醒来的可能性。使用泡沫垫和真空固定器来限制扫描中的运动伪影。在过去的39个月里，已经从220名4岁以下的儿童中成功获取了380多个MRI数据集。实施的措施允许儿童在扫描过程中保持睡眠，并允许获取数据，总体成功率为97%。提出的方法极大地改进了目前的儿科影像技术，并可容易地在其他研究和临床环境中实施，以促进和进一步改善儿科神经影像。
Etiological studies of many neurological and psychiatric disorders are increasingly turning toward longitudinal investigations of infant brain development in order to discern predisposing structural and/or functional differences prior to the onset of overt clinical symptoms. While MRI provides a noninvasive window into the developing brain, MRI of infants and toddlers is challenging due to the modality’s extreme motion sensitivity and children’s difficulty in remaining still during image acquisition. Here, we outline a broad research protocol for successful MRI of children under 4 years of age during natural, non-sedated sleep. All children were imaged during natural, non-sedated sleep. Active and passive measures to reduce acoustic noise were implemented to reduce the likelihood of the children waking up during acquisition. Foam cushions and vacuum immobilizers were used to limit intra-scan motion artifacts. More than 380 MRI datasets have been successfully acquired from 220 children younger than 4 years of age within the past 39 months. Implemented measures permitted children to remain asleep for the duration of the scan and allowed the data to be acquired with an overall 97% success rate. The proposed method greatly advances current pediatric imaging techniques and may be readily implemented in other research and clinical settings to facilitate and further improve pediatric neuroimaging.
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影响因子：
3.6
作者：
de Bie, Henrica M. A.;Boersma, Maria;Wattjes, Mike P.;Adriaanse, Sofie;Vermeulen, R. Jeroen;Oostrom, Kim J.;Huisman, Jaap;Veltman, Dick J.;Delemarre-Van de Waal, Henriette A.
通讯作者：
Delemarre-Van de Waal, Henriette A.
影响因子：
16.2
作者：
Giedd, Jay N.;Rapoport, Judith L.
通讯作者：
Rapoport, Judith L.
影响因子：
5.7
作者：
Nossin-Manor, Revital;Card, Dallas;Sled, John G.
通讯作者：
Sled, John G.
影响因子：
3.3
作者：
Deoni, Sean C. L.;Rutt, Brian K.;Jones, Derek K.
通讯作者：
Jones, Derek K.
DOI：
10.3791/1309
发表时间：
2009-07-30
期刊：
Journal of visualized experiments : JoVE
影响因子：
--
作者：
Raschle, Nora M;Lee, Michelle;Gaab, Nadine
通讯作者：
Gaab, Nadine